UDP-glucose—glycoprotein glucose phosphotransferase
In enzymology, an UDP-glucose—glycoprotein glucose phosphotransferase (EC 2.7.8.19) is an enzyme that catalyzes the chemical reaction
- UDP-glucose + glycoprotein D-mannose UMP + glycoprotein 6-(D-glucose-1-phospho)-D-mannose
| UDP-glucose-glycoprotein glucose phosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.19 | ||||||||
| CAS no. | 84861-40-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UDP-glucose and glycoprotein D-mannose, whereas its two products are UMP and glycoprotein 6-(D-glucose-1-phospho)-D-mannose.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase. Other names in common use include UDP-glucose:glycoprotein glucose-1-phosphotransferase, GlcPTase, Glc-phosphotransferase, and uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase.
References
- Koro LA, Marchase RB (1982). "A UDP-glucose:glycoprotein glucose-1-phosphotransferase in embryonic chicken neural retina". Cell. 31 (3 Pt 2): 739–48. doi:10.1016/0092-8674(82)90328-2. PMID 6297779.
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