UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase

UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.33, UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, WecA, WecA transferase, UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase, GlcNAc-P-P-Und synthase, GPT, TagO, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetylglucosaminephosphotransferase) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-alpha-D-glucosaminephosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-alpha-D-glucosamine + ditrans, octacis-undecaprenyl phosphate UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans, octacis-undecaprenol
UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
Identifiers
EC no.2.7.8.33
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme catalyses the synthesis of ditrans, octacis-undecaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate.

References
  1. Al-Dabbagh B, Mengin-Lecreulx D, Bouhss A (November 2008). "Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA". Journal of Bacteriology. 190 (21): 7141–6. doi:10.1128/jb.00676-08. PMC 2580700. PMID 18723618.
  2. Lehrer J, Vigeant KA, Tatar LD, Valvano MA (April 2007). "Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide". Journal of Bacteriology. 189 (7): 2618–28. doi:10.1128/jb.01905-06. PMC 1855806. PMID 17237164.
  3. Rush JS, Rick PD, Waechter CJ (March 1997). "Polyisoprenyl phosphate specificity of UDP-GlcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli". Glycobiology. 7 (2): 315–22. doi:10.1093/glycob/7.2.315. PMID 9134438.
  4. Soldo B, Lazarevic V, Karamata D (July 2002). "tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168". Microbiology. 148 (Pt 7): 2079–87. doi:10.1099/00221287-148-7-2079. PMID 12101296.
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