Triethylenemelamine

Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.[1]

Triethylenemelamine
Clinical data
ATC code
  • None
Identifiers
  • 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.076
Chemical and physical data
FormulaC9H12N6
Molar mass204.237 g·mol−1
3D model (JSmol)
  • C1CN1c2nc(nc(n2)N3CC3)N4CC4
  • InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2 ☒N
  • Key:IUCJMVBFZDHPDX-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

It can cause chromatid aberrations in cell models.[2]

See also

References
  1. Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA (October 2014). "Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
  2. Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–326. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.
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