Transcription factor DP
In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [1] and negatively regulates the G1-S transition.
| DP | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer | |||||||||
| Identifiers | |||||||||
| Symbol | DP | ||||||||
| Pfam | PF08781 | ||||||||
| InterPro | IPR014889 | ||||||||
| PROSITE | PDOC00359 | ||||||||
| MEROPS | S9 | ||||||||
| SCOP2 | 1c5e / SCOPe / SUPFAM | ||||||||
| CAZy | GT1 | ||||||||
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References
- Rubin SM, Gall AL, Zheng N, Pavletich NP (December 2005). "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release". Cell. 123 (6): 1093–106. doi:10.1016/j.cell.2005.09.044. PMID 16360038. S2CID 6158027.
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