Trans-2-decenoyl-(acyl-carrier protein) isomerase
In enzymology, a trans-2-decenoyl-[acyl-carrier protein] isomerase (EC 5.3.3.14) is an enzyme that catalyzes the chemical reaction
- trans-dec-2-enoyl-[acyl-carrier-protein] cis-dec-3-enoyl-[acyl-carrier-protein]
| Trans-2-decenoyl-(acyl-carrier protein) isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.3.14 | ||||||||
| CAS no. | 9030-80-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hence, this enzyme has one substrate, [[trans-dec-2-enoyl-[acyl-carrier-protein]]], and one product, [[cis-dec-3-enoyl-[acyl-carrier-protein]]].
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase. Other names in common use include beta-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, and FabM.
References
- Brock DJ, Kass LR, Bloch K (1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–40. PMID 4863740.
- Bloch K (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2 (7): 193–202. doi:10.1021/ar50019a001.
- Marrakchi H, Choi KH, Rock CO (2002). "A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae". J. Biol. Chem. 277 (47): 44809–16. doi:10.1074/jbc.M208920200. PMID 12237320.
- Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.
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