Thyroid-hormone transaminase
In enzymology, a thyroid-hormone transaminase (EC 2.6.1.26) is an enzyme that catalyzes the chemical reaction
- L-3,5,3'-triiodothyronine + 2-oxoglutarate 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
| Thyroid-hormone transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.26 | ||||||||
| CAS no. | 51004-29-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are L-3,5,3'-triiodothyronine and 2-oxoglutarate, whereas its two products are [[3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate]] and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It employs one cofactor, pyridoxal phosphate.
References
- Soffer RL, Hechtman P, Savage M (1973). "L-Triiodothyronine aminotransferase". J. Biol. Chem. 248 (4): 1224–30. PMID 4686924.
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