Tetrahydromethanopterin S-methyltransferase
In enzymology, a tetrahydromethanopterin S-methyltransferase (EC 2.1.1.86) is an enzyme that catalyzes the chemical reaction
- 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate
| tetrahydromethanopterin S-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.86 | ||||||||
| CAS no. | 103406-60-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 5-methyl-5,6,7,8-tetrahydromethanopterin and 2-mercaptoethanesulfonate (coenzyme M), whereas its two products are 5,6,7,8-tetrahydromethanopterin and 2-(methylthio)ethanesulfonate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase. This enzyme is also called tetrahydromethanopterin methyltransferase. This enzyme participates in folate biosynthesis.
References
- Sauer FD (April 1986). "Tetrahydromethanopterin methyltransferase, a component of the methane synthesizing complex of Methanobacterium thermoautotrophicum". Biochemical and Biophysical Research Communications. 136 (2): 542–7. doi:10.1016/0006-291X(86)90474-2. PMID 3085670.
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