Terephthalate 1,2-cis-dihydrodiol dehydrogenase
In enzymology, a terephthalate 1,2-cis-dihydrodiol dehydrogenase (EC 1.3.1.61) is an enzyme that catalyzes the chemical reaction:
- cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ 3,4-dihydroxybenzoate + CO2 + NADH
| terephthalate 1,2-cis-dihydrodiol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate and NAD+, whereas its 3 products are 3,4-dihydroxybenzoate, CO2, and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in 2,4-dichlorobenzoate degradation.
References
- Wang YZ, Zhou Y, Zylstra GJ (1995). "Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D". Environ. Health Perspect. 103 (Suppl. 5): 9–12. PMC 1519302. PMID 8565920.
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