TUB (gene)

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.[5][6]

TUB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor
External IDsOMIM: 601197 MGI: 2651573 HomoloGene: 31147 GeneCards: TUB
Orthologs
SpeciesHumanMouse
Entrez

7275

22141

Ensembl

ENSG00000166402

ENSMUSG00000031028

UniProt

P50607

P50586

RefSeq (mRNA)

NM_003320
NM_177972

NM_021885

RefSeq (protein)

NP_003311
NP_813977

NP_068685

Location (UCSC)Chr 11: 8.02 – 8.11 MbChr 7: 108.55 – 108.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

TUB (gene) has been shown to interact with PLCG1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000166402 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031028 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–90. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280. S2CID 15670925.
  6. "Entrez Gene: TUB tubby homolog (mouse)".
  7. Kapeller, R; Moriarty A; Strauss A; Stubdal H; Theriault K; Siebert E; Chickering T; Morgenstern J P; Tartaglia L A; Lillie J (Aug 1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. UNITED STATES. 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. ISSN 0021-9258. PMID 10455176.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P50607 (Human Tubby protein homolog) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: P50586 (Mouse Tubby protein) at the PDBe-KB.


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