TRNA (guanine6-N2)-methyltransferase
TRNA (guanine6-N2)-methyltransferase (EC 2.1.1.256, methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine6 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
| TRNA (guanine6-N2)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.256 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme specifically methylates guanine6 at N2 in tRNA.
References
- Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ (September 2011). "Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14". Nucleic Acids Research. 39 (17): 7641–55. doi:10.1093/nar/gkr475. PMC 3177210. PMID 21693558.
External links
- TRNA+(guanine6-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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