tRNA-queuosine beta-mannosyltransferase
In enzymology, a tRNA-queuosine beta-mannosyltransferase (EC 2.4.1.110) is an enzyme that catalyzes the chemical reaction
- GDP-mannose + tRNAAsp-queuosine GDP + tRNAAsp-O-5"-beta-D-mannosylqueuosine
| tRNA-queuosine beta-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.110 | ||||||||
| CAS no. | 9055-06-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are GDP-mannose and tRNAAsp-queuosine, whereas its two products are GDP and tRNAAsp-O-5''-beta-D-mannosylqueuosine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:tRNAAsp-queuosine O-5"-beta-D-mannosyltransferase.
References
- Okada N, Nishimura S (1977). "Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver". Nucleic Acids Res. 4 (8): 2931–8. doi:10.1093/nar/4.8.2931. PMC 342620. PMID 20603.
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