TRAK2

TRAK2
Identifiers
Aliases	TRAK2, ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98, trafficking kinesin protein 2
External IDs	OMIM: 607334 MGI: 1918077 HomoloGene: 22861 GeneCards: TRAK2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	201,451,500 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	58,973,430 bp[2]
RNA expression pattern
	Top expressed in
	optic nerve; ; cancellous bone; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; right ventricle; ; subthalamic nucleus; ; corpus callosum; ; internal globus pallidus; ; pons; ; secondary oocyte;
	Top expressed in
	globus pallidus; ; otolith organ; ; digastric muscle; ; utricle; ; bone marrow; ; soleus muscle; ; vastus lateralis muscle; ; superior cervical ganglion; ; temporal muscle; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; GABA receptor binding; kinesin binding; TPR domain binding; enzyme binding; myosin binding;
Cellular component	cytoplasm; endosome; plasma membrane; early endosome; mitochondrion; nucleus; dendrite cytoplasm; dendrite; neuron projection; neuronal cell body; axonal growth cone; cytoplasmic vesicle; axon cytoplasm;
Biological process	regulation of transcription by RNA polymerase II; protein targeting; protein O-linked glycosylation; anterograde dendritic transport of mitochondrion; endosome to lysosome transport; dendrite morphogenesis; negative regulation of axonogenesis; dendritic transport of mitochondrion; anterograde axonal transport; protein localization; neurogenesis; vesicle transport along microtubule; mitochondrion distribution; anterograde axonal transport of mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	66008
	70827
	ENSG00000115993
	ENSMUSG00000026028
	O60296
	n/a
	NM_015049
	NM_172406
	NP_055864
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.[5][6][7]

Interactions

TRAK2 has been shown to interact with Kir2.1[8] and GABRB2.[9]

References

GRCh38: Ensembl release 89: ENSG00000115993 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026028 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
"Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".
Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.
Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". The Journal of Biological Chemistry. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". The Journal of Biological Chemistry. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Fransson S, Ruusala A, Aspenström P (Jun 2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochemical and Biophysical Research Communications. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.
Smith MJ, Pozo K, Brickley K, Stephenson FA (Sep 2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". The Journal of Biological Chemistry. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115993 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026028 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11161814-5] Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.

[pmid16380713-6] Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.

[entrez-7] "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".

[pmid16895905-8] Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.

[pmid12034717-9] Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

TRAK2

Interactions

References

Further reading