TNRC6B

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[5]

TNRC6B
Identifiers
AliasesTNRC6B, trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B, GDSBA
External IDsOMIM: 610740 MGI: 2443730 HomoloGene: 66194 GeneCards: TNRC6B
Orthologs
SpeciesHumanMouse
Entrez

23112

213988

Ensembl

ENSG00000100354

ENSMUSG00000047888

UniProt

Q9UPQ9

Q8BKI2

RefSeq (mRNA)

NM_015088
NM_001024843
NM_001162501

NM_144812
NM_177124

RefSeq (protein)

NP_001020014
NP_001155973
NP_055903

NP_659061
NP_796098

Location (UCSC)Chr 22: 40.04 – 40.34 MbChr 15: 80.6 – 80.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TNRC6B has been shown to interact with EIF2C2.[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000100354 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047888 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TNRC6B trinucleotide repeat containing 6B".
  6. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. S2CID 8136380.
  7. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642. S2CID 2740901.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.