TMEM106C

The TMEM106C gene is located on the long arm of the 12th chromosome. It is found at position 12q13.1. This gene spans from 48357225 to 48362667 on chromosome 12.[7] This gene is in between COL2A1, the human type II collagen gene, and VDR, the human Vitamin D Receptor gene.[8] This protein is found to be an integral part of the endoplasm reticulum membrane.[9]

The N and C-terminal ends of the protein are found in the cytosol of the cell [10]

The TMEM106A protein has a molecular weight of 27.9 kdal with a PI of 6.325.[11] It has 250 amino acids, 230 of which are in the domain of unknown function. No signal peptide has been found for this protein but TMEM106C has transmembrane regions which gives evidence for an internal signal peptide.[12] This protein spans the ER membrane 2 times.[10] There is evidence that these transmembrane regions take on helical structures.[13] The predicted structure of the protein is shown to the left:

TMEM106C is valine-rich with no tryptophan.[11]

There are several areas for post-translational modification for TMEM106A including:[14]

• Phosphorylation[15]
• Kinase-Specific Phosphoylation[16]
• N-glycosylation[17]

This gene is highly expressed. TMEM106C is expressed 4.9 times the average gene.[7] TMEM106C has ubiquitous expression. It can be found expressed in many tissues types. Tissue types with high expression included the adrenal gland, eye, reproductive organs, cervix and blood. High expression was found using EST and GEO data.

Expression Patterns found in Various Tissue Types [18]

This gene is also found overexpressed in cancer cells. This gene has found to be expressed three times more in adrenal tumor and twice more in bladder carcinoma and retinoblastoma than normal expression.

Expression Levels found in Leukemia[19]

It is also found to be highly expressed in breast (mammary gland) tumor, cervical tumor, esophageal tumor, leukemia, liver tumor; lung tumor, pancreatic tumor, prostate cancer, and soft tissue/muscle tissue tumor.[20]

TMEM106C is found in all stages of development from embryoid body, blastocyst, fetus, infant, juvenile and adult.[21]