TLR4-IN-C34

TLR4-IN-C34 (or C34) is a drug which acts as a potent and selective antagonist of Toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects.[1][2][3]

TLR4-IN-C34
Identifiers
  • [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-propan-2-yloxyoxan-2-yl]methyl acetate
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC17H27NO9
Molar mass389.401 g·mol−1
3D model (JSmol)
  • CC(C)O[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C
  • InChI=1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1
  • Key:KMIQMFHPUJUDMC-HHARLNAUSA-N

See also

References
  1. Adegoke EO, Adeniran SO, Zeng Y, Wang X, Wang H, Wang C, et al. (June 2019). "Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells". Journal of Applied Toxicology. 39 (6): 832–843. doi:10.1002/jat.3771. PMID 30671980. S2CID 58948493.
  2. Lee TH, Park D, Kim YJ, Lee I, Kim S, Oh CT, et al. (April 2020). "Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis". International Journal of Molecular Medicine. 45 (4): 1130–1140. doi:10.3892/ijmm.2020.4495. PMC 7053870. PMID 32124946.
  3. Sivak KV, Stosman KI, Rassokha TA, Aleksandrov AG, Kuzmich NN, Orshanskaya YR, et al. (October 2020). "The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats". Bulletin of Experimental Biology and Medicine. 169 (6): 795–797. doi:10.1007/s10517-020-04981-9. PMID 33098506.


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