Susan Brain

Susan Diana Brain FBPhS is a professor of pharmacology at the School of Cardiovascular Medicine and Sciences at King's College London where she has worked since 1989.[1]

Susan Brain

FBPhS
Born
Susan Diana Brain
Alma materUniversity of London (PhD)
Scientific career
FieldsPhysiology
Pharmacology
InstitutionsKing's College London
ThesisRelationship between lipolysis and prostaglandin biosynthesis in adipose tissue (1981)
Websitewww.kcl.ac.uk/people/professor-susan-brain

Education

Brain completed a PhD in pharmacology at University College London in 1981.

Career and research

Brain held a postdoctoral post at the Institute of Dermatology. In 1989 she took up a lectureship at King's College London, where she was promoted to Reader in 1993[2] and in 1998 she was made Professor of Pharmacology at the School of Cardiovascular Medicine, where since 2005 she has been Head of the Vascular Biology and Inflammation Section.[3] She was also Head of the Pharmacology and Therapeutics Education Department between 2011 and 2018.

Brain's research investigates the role of sensory nerves in vascular inflammation.[4] In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular vasodilator.[5] More recently her research found that the gene TRPC5 can help protect against pain in arthritis[6] and that the gene TRPA1 is essential for the vascular response when being exposed to cold environments.[7]

Awards and honours

In 2018 she was elected as honorary fellow of the British Pharmacological Society.[8]

References
  1. Susan Brain's ORCID 0000-0002-9684-8342
  2. "Susan Brain – CGRP Education & Research Forum". 20 March 2017. Retrieved 17 October 2019.
  3. "Professor Susan Brain". www.kcl.ac.uk. Archived from the original on 17 October 2019. Retrieved 17 October 2019.
  4. Sousa-Valente, João; Brain, Susan D. (2018). "A historical perspective on the role of sensory nerves in neurogenic inflammation". Seminars in Immunopathology. 40 (3): 229–236. doi:10.1007/s00281-018-0673-1. ISSN 1863-2297. PMC 5960476. PMID 29616309.
  5. Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a potent vasodilator". Nature. 313 (5997): 54–56. doi:10.1038/313054a0. ISSN 0028-0836. PMID 3917554. S2CID 4329128.
  6. Alawi, Khadija M; Russell, Fiona A; Aubdool, Aisah A; Srivastava, Salil; Riffo-Vasquez, Yanira; Baldissera, Lineu; Thakore, Pratish; Saleque, Nurjahan; Fernandes, Elizabeth S; Walsh, David A; Brain, Susan D (2017). "Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation". Annals of the Rheumatic Diseases. 76 (1): 252–260. doi:10.1136/annrheumdis-2015-208886. ISSN 0003-4967. PMC 5264234. PMID 27165180.
  7. Aubdool, Aisah A.; Graepel, Rabea; Kodji, Xenia; Alawi, Khadija M.; Bodkin, Jennifer V.; Srivastava, Salil; Gentry, Clive; Heads, Richard; Grant, Andrew D.; Fernandes, Elizabeth S.; Bevan, Stuart (2014). "TRPA1 is essential for the vascular response to environmental cold exposure". Nature Communications. 5 (1): 5732. doi:10.1038/ncomms6732. ISSN 2041-1723. PMC 4284811. PMID 25501034.
  8. "Professor Susan Brain, Honorary Fellows". British Pharmacological Society. Archived from the original on 17 October 2019. Retrieved 17 October 2019.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.