Steven Clarke

Steven G. Clarke, (born November 19, 1949) an American biochemist, is a director of the UCLA Molecular Biology Institute,[1] a professor of chemistry and biochemistry at UCLA biochemistry department. Clarke heads a laboratory at UCLA's department of chemistry and biochemistry. Clarke is famous for his work on molecular damage and discoveries of novel molecular repair mechanisms.

For other people named Steven Clarke, see Steven Clarke (disambiguation).

Steven Clarke
Born (1949-11-19) November 19, 1949
Los Angeles, California
EducationPomona College, UCLA Brain Research Institute, Harvard University (Ph.D.)
Known forMolecular repair mechanisms, biochemistry of brains, Alzheimer's disease
Scientific career
FieldsBiochemistry
InstitutionsGlynn Research Laboratories (Bodmin, Cornwall), UCLA, University of California, Berkeley
Doctoral advisorGuido Guidotti
Other academic advisorsDaniel Koshland

Clarke has been on the faculty of the UCLA Department of Chemistry and Biochemistry since 1978. He is currently a professor of biochemistry and director of the UCLA Molecular Biology Institute.

Early life and education

He was born in Los Angeles and attended public schools in Altadena and Pasadena, California.

He did his undergraduate work at Pomona College, a private institution, in Claremont, majoring in Chemistry and Zoology and graduating in 1970.[2] During this time, he did undergraduate research at the UCLA Brain Research Institute with James E. Skinner and Professor Donald B. Lindsley on neural mechanisms of attention. He was also an NIH fellow in the laboratory of Peter Mitchell at Glynn Research Laboratories in Bodmin, England studying mitochondrial amino acid transport.

He obtained a PhD in biochemistry and molecular biology from Harvard University working as an NSF Fellow with Professor Guido Guidotti on membrane protein-detergent interactions and the identification of the major rat liver mitochondrial polypeptides as enzymes of the urea cycle. He returned to California to do postdoctoral work as a Miller Fellow at the University of California, Berkeley, with Professor Daniel Koshland, identifying membrane receptors for bacterial chemotaxis.

Career

Clarke's research at UCLA has focused on roles of novel protein methyltransferases in aging and biological regulation highlighted by discoveries of the protein repair L-isoaspartyl methyltransferase,[3] the isoprenylcysteine protein methyltransferase,[4] and the protein phosphatase 2A methyltransferase.[5]

He was a visiting scholar at Princeton University (1986–87) and at the University of Washington (2004-2005).

Clarke has conducted research on the biochemistry of brains and Alzheimer's disease[6] since 1990.[7]

References
  1. "Departments". Archived from the original on 9 April 2008. Retrieved 24 March 2008.
  2. "2020 Blaisdell Distinguished Alumni Award Winners". Pomona College. 22 April 2020. Retrieved 11 March 2021.
  3. Brennan, T V; Anderson, J W; Jia, Z C; Waygood, E B; Clarke, S (1994). "Repair of spontaneously deamidated HPR phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase". J. Biol. Chem. 269 (40): 24586–24595. doi:10.1016/S0021-9258(17)31432-1. PMID 7929130.
  4. Hrycyna, Christine A.; Yang, Melody C.; Clarke, Steven (1994). "Protein Carboxyl Methylation in Saccharomyces cerevisiae: Evidence for STE14-Dependent and STE14-Independent Pathways". Biochemistry. 33 (32): 9806–9812. doi:10.1021/bi00198a053. PMID 8068661.
  5. Xie, H Y; Clarke, S (1994). "Protein phosphatase-2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain". J. Biol. Chem. 269 (3): 1981–1984. doi:10.1016/S0021-9258(17)42124-7. PMID 8294450.
  6. Roher, A. E.; Lowenson, J. D.; Clarke, S.; Woods, A. S.; Cotter, R. J.; Gowing, E.; Ball, M. J. (1993). "Beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease". Proceedings of the National Academy of Sciences. 90 (22): 10836–10840. Bibcode:1993PNAS...9010836R. doi:10.1073/pnas.90.22.10836. PMC 47873. PMID 8248178.
  7. University of California, Los Angeles (19 August 2019). "Biochemists discover new insights into what may go awry in brains of Alzheimer's patients". Science Daily. Retrieved 19 February 2021.
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