Stephan A. Mayer

Stephan A. Mayer is an American neurologist and critical care physician who currently serves as Director of Neurocritical Care and Emergency Neurology Services for the Westchester Medical Center Health System.[1][2] Mayer is most noted for his research in subarachnoid and intracerebral hemorrhage, acute ischemic stroke, cardiac arrest, coma, status epilepticus, brain multimodality monitoring, therapeutic temperature modulation, and outcomes after severe brain injury. He has gained media attention for popularizing the concept that physicians have historically underestimated the brain’s resilience and capacity for recovery.[3] He has authored over 400 original research publications, 200 chapters and review articles, and 370 abstracts.[4]

Research and career

Mayer originated the concept of ultra-early hemostatic therapy for intracerebral hemorrhage (ICH), and served as principal investigator of a multinational multicenter testing program evaluating recombinant factor VIIa for this indication.[5][6][7][8]

Mayer predominantly uses invasive brain multimodality monitoring to guide therapy and increase situational awareness in the treatment of coma.[9] Other contributions to the field of neurocritical care that Mayer and colleagues have introduced include the Bedside Shivering Assessment Scale[10] and the Columbia Anti-Shivering Protocol,[11] both of which are used to facilitate therapeutic temperature modulation throughout the world; the Modified Fisher Scale,[12] the most widely-used scale to assess vasospasm risk after subarachnoid hemorrhage; and the concept of “CTA-for-All” for stroke imaging, to increase the likelihood of successful endovascular reperfusion.[13][14]

Mayer's work in helping victims of severe brain injury has been featured in two books, Back from the Brink by Edward Sylvester[15] and Cheating Death by CNN medical correspondent Sanjay Gupta.[16][17]

Honors
  • 2005 – Distinguished Lecturer Award, Zeenat Qureshi Stroke Research Center, University of Medicine & Dentistry of New Jersey
  • 2006 – Elected as Fellow of the American College of Critical Care Medicine (FCCM)
  • 2014 –Lifesaver Award, American Heart Association, New York City Chapter
  • 2019– First Leon Prockop Distinguished Lecture in Neurology, University of South Florida, Tampa, FL
  • 2019. – Elected as Fellow of the Neurocritical Care Society (FNCS)
  • 2020 – Drs. Michael E. Cohen and Patricia K. Duffner Annual Lecture in Neurology, University of Buffalo, Buffalo, NY

Books edited or co-edited
  • Merritt’s Neurology, 14th Edition. (co-edited)[18]
  • On Call: Neurology, 4th Edition.(edited)[19]
  • Mount Sinai Expert Guides: Critical Care.(co-edited)[20]
  • Neuroprotection in Neurocritical Care and Perioperative Medicine.(co-edited)[21]
  • New Insights in Intracerebral Haemorrhage.<(co-edited)[22]
  • Intracerebral Haemorrhage.(co-edited)[23]
  • Therapeutic Hypothermia.(co-edited)[24]

Publications
  • Stephan A Mayer, Nikolai C Brun, Kamilla Begtrup, Joseph Broderick, Stephen Davis, Michael N Diringer, Brett E Skolnick, Thorsten Steiner. "Recombinant activated factor VII for acute intracerebral hemorrhage".[25]
  • Stephan A Mayer, Nikolai C Brun, Kamilla Begtrup, Joseph Broderick, Stephen Davis, Michael N Diringer, Brett E Skolnick, and Thorsten Steiner. "Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage".[26]
  • Stephan A Mayer, Jan Claassen, Johnny Lokin, Felicia Mendelsohn, Lyle J Dennis, and Brian-Fred Fitzsimmons. "Refractory status epilepticus: frequency, risk factors, and impact on outcome".[27]
  • Stephan A Mayer, Angela Lignelli, Matthew E Fink, Deborah B Kessler, Carole E Thomas, Rupendra Swarup, Ronald L Van Heertum. "Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study".[28]
  • Stephan A Mayer, and Fred Rincon. "Treatment of intracerebral haemorrhage".[29]
  • Stephan A. Mayer. “Ultra-early hemostatic therapy for intracerebral hemorrhage.[30]
  • Stephan A Mayer, Nikolai C Brun, Kamilla Begtrup, Joseph Broderick, Stephen Davis, Michael N Diringer, Brett E Skolnick, Thorsten Steiner. "Recombinant activated factor VII for acute intracerebral hemorrhage".[31]
  • Stephan A, Mayer SA, Tanuwong Viarasilpa, Nicha Panyavachiraporn, Megan Brady, Dawn Scozzai, Marilyn Van Harn, Daniel Miller, Angelos Katramados, Hebah Hefzy, Shaneela Malik, Horia Marin H, Max Kole, Alex B. Chebl, Christopher Lewandowski, Panos Mitsias., CTA-for-All: Impact of emergency computed tomographic angiography for all stroke patients presenting within 24 hours of onset.[32]

References
  1. "Mayer, Stephan A. | Physicians". www.westchestermedicalcenter.org. Retrieved 2022-02-26.
  2. College, New York Medical. "Stephan Mayer, M.D." www.nymc.edu. Retrieved 2022-02-26.
  3. JOURNAL, Thomas M. BurtonStaff Reporter of THE WALL STREET (2005-11-23). "In a Stroke Patient, Doctor Sees Power Of Brain to Recover". Wall Street Journal. ISSN 0099-9660. Retrieved 2022-02-26.
  4. Stephan A. Mayer publications indexed by Google Scholar
  5. Mayer, Stephan A. (2003-01-01). "Ultra-Early Hemostatic Therapy for Intracerebral Hemorrhage". Stroke. 34 (1): 224–229. doi:10.1161/01.STR.0000046458.67968.E4. PMID 12511778. S2CID 179042.
  6. Mayer, Stephan A.; Frontera, Jennifer A.; Jankowitz, Brian; Kellner, Christopher P.; Kuppermann, Nathan; Naik, Bhiken I.; Nishijima, Daniel K.; Steiner, Thorsten; Goldstein, Joshua N.; CNS Bleeding/Neurosurgery Subgroup of the NHLBI Hemostasis Trials Outcomes Working Group (2021-09-02). "Recommended Primary Outcomes for Clinical Trials Evaluating Hemostatic Agents in Patients With Intracranial Hemorrhage: A Consensus Statement". JAMA Network Open. 4 (9): e2123629. doi:10.1001/jamanetworkopen.2021.23629. ISSN 2574-3805. PMID 34473266. S2CID 237388127.
  7. Aquino, Camila C.; Borg Debono, Victoria; Germini, Federico; Pete, Drashti; Kempton, Christine L.; Young, Guy; Sidonio, Robert; Croteau, Stacy E.; Dunn, Amy L.; Key, Nigel S.; Iorio, Alfonso (2021-02-06). "Outcomes for studies assessing the efficacy of hemostatic therapies in persons with congenital bleeding disorders". Haemophilia. 27 (2): 211–220. doi:10.1111/hae.14247. ISSN 1351-8216. PMID 33550614. S2CID 231867860.
  8. Gladstone, David (2018-10-03). ""Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy: SPOTLIGHT". David Gladstone. {{cite journal}}: Cite journal requires |journal= (help)
  9. "An aggressive approach with no guarantees". Scienceline. 2014-01-15. Retrieved 2022-02-26.
  10. Badjatia, Neeraj; Strongilis, Evangelia; Gordon, Errol; Prescutti, Mary; Fernandez, Luis; Fernandez, Andres; Buitrago, Manuel; Schmidt, J. Michael; Ostapkovich, Noeleen D.; Mayer, Stephan A. (December 2008). "Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale". Stroke. 39 (12): 3242–3247. doi:10.1161/STROKEAHA.108.523654. ISSN 1524-4628. PMID 18927450. S2CID 1511543.
  11. Choi, H. Alex; Ko, Sang-Bae; Presciutti, Mary; Fernandez, Luis; Carpenter, Amanda M.; Lesch, Christine; Gilmore, Emily; Malhotra, Rishi; Mayer, Stephan A.; Lee, Kiwon; Claassen, Jan (June 2011). "Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol". Neurocritical Care. 14 (3): 389–394. doi:10.1007/s12028-010-9474-7. ISSN 1556-0961. PMID 21210305. S2CID 21272649.
  12. Frontera, Jennifer A.; Claassen, Jan; Schmidt, J. Michael; Wartenberg, Katja E.; Temes, Richard; Connolly, E. Sander; Macdonald, R. Loch; Mayer, Stephan A. (2006-07-01). "Prediction of Symptomatic Vasospasmafter Subarachnoid Hemorrhage: The Modified Fisher Scale". Neurosurgery. 59 (1): 21–27. doi:10.1227/01.NEU.0000218821.34014.1B. ISSN 0148-396X. PMID 16823296.
  13. "Shifting Paradigms for Intensive Care of Severe Brain Injury". Dana Foundation. Retrieved 2022-02-26.
  14. "Dr. Stephan Mayer: "Loss of Consciousness a Marker of Early Brain Injury in Subarachnoid Hemorrhage" | Mount Sinai - New York". Mount Sinai Health System. Retrieved 2022-02-26.
  15. Sylvester, Edward J. (2004). Back from the brink : how crises spur doctors to new discoveries about the brain. New York: Dana Press. ISBN 0-9723830-4-2. OCLC 52251207.
  16. Sylvester, Edward J. (2004). Back from the Brink: How Crises Spur Doctors to New Discoveries about the Brain. Dana Press. ISBN 978-0-9723830-4-2.
  17. Gupta, Sanjay (2009-10-12). Cheating Death: The Doctors and Medical Miracles that Are Saving Lives Against All Odds. Grand Central Publishing. ISBN 978-0-446-55876-1.
  18. Louis, Elan D. (2021). Merritt's neurology. Elan D. Louis, Stephan A. Mayer, H. Houston Merritt (Fourteenth ed.). Baltimore. ISBN 978-1-9751-4123-3. OCLC 1255795224.{{cite book}}: CS1 maint: location missing publisher (link)
  19. Marshall, Randolph S. (2007). On call neurology. Stephan A. Mayer (3rd ed.). Philadelphia, PA: Saunders/Elsevier. ISBN 978-1-4160-2375-3. OCLC 76183541.
  20. Critical care. Stephan A. Mayer, Janet M. Shapiro, Umesh K. Gidwani, John M. Oropello. Hoboken, NJ. 2021. ISBN 978-1-119-29325-5. OCLC 1182019415.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  21. Neuroprotection in critical care and perioperative medicine. David L. Reich, Stephan A. Mayer, Suzan Uysal. New York, NY. 2018. ISBN 978-0-19-028025-3. OCLC 1002211072.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  22. New insights in intracerebral hemorrhage. Kazunori Toyoda, Craig S. Anderson, Stephan A. Mayer. Basel. 2015. ISBN 978-3-318-05597-9. OCLC 932124179.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  23. Intracerebral hemorrhage. J. R. Carhuapoma, Stephan A. Mayer, D. F. Hanley. Cambridge: Cambridge University Press. 2010. ISBN 978-0-511-69131-7. OCLC 646068232.{{cite book}}: CS1 maint: others (link)
  24. Therapeutic hypothermia. Stephan A. Mayer, Daniel Sessler. New York: Marcel Dekker. 2005. ISBN 978-0-8247-5478-5. OCLC 56649877.{{cite book}}: CS1 maint: others (link)
  25. Mayer, Stephan A.; Brun, Nikolai C.; Begtrup, Kamilla; Broderick, Joseph; Davis, Stephen; Diringer, Michael N.; Skolnick, Brett E.; Steiner, Thorsten (2005-02-24). "Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage". New England Journal of Medicine. 352 (8): 777–785. doi:10.1056/NEJMoa042991. ISSN 0028-4793. PMID 15728810.
  26. Mayer, Stephan A.; Brun, Nikolai C.; Begtrup, Kamilla; Broderick, Joseph; Davis, Stephen; Diringer, Michael N.; Skolnick, Brett E.; Steiner, Thorsten (2008-05-15). "Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage". New England Journal of Medicine. 358 (20): 2127–2137. doi:10.1056/NEJMoa0707534. hdl:10067/688040151162165141. ISSN 0028-4793. PMID 18480205.
  27. Mayer, Stephan A.; Claassen, Jan; Lokin, Johnny; Mendelsohn, Felicia; Dennis, Lyle J.; Fitzsimmons, Brian-Fred (2002-02-01). "Refractory Status Epilepticus: Frequency, Risk Factors, and Impact on Outcome". Archives of Neurology. 59 (2): 205–210. doi:10.1001/archneur.59.2.205. ISSN 0003-9942. PMID 11843690.
  28. Mayer, Stephan A.; Lignelli, Angela; Fink, Matthew E.; Kessler, Deborah B.; Thomas, Carole E.; Swarup, Rupendra; Van Heertum, Ronald L. (1998-09-01). "Perilesional Blood Flow and Edema Formation in Acute Intracerebral Hemorrhage". Stroke. 29 (9): 1791–1798. doi:10.1161/01.STR.29.9.1791. PMID 9731596.
  29. Mayer, Stephan A.; Rincon, Fred (2005-10-01). "Treatment of intracerebral haemorrhage". The Lancet Neurology. 4 (10): 662–672. doi:10.1016/S1474-4422(05)70195-2. ISSN 1474-4422. PMID 16168935. S2CID 45835081.
  30. Mayer, Stephan A. (2003-01-01). "Ultra-Early Hemostatic Therapy for Intracerebral Hemorrhage". Stroke. 34 (1): 224–229. doi:10.1161/01.STR.0000046458.67968.E4. PMID 12511778. S2CID 179042.
  31. Mayer, Stephan A.; Brun, Nikolai C.; Begtrup, Kamilla; Broderick, Joseph; Davis, Stephen; Diringer, Michael N.; Skolnick, Brett E.; Steiner, Thorsten (2005-02-24). "Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage". New England Journal of Medicine. 352 (8): 777–785. doi:10.1056/NEJMoa042991. ISSN 0028-4793. PMID 15728810.
  32. Mayer, Stephan A.; Viarasilpa, Tanuwong; Panyavachiraporn, Nicha; Brady, Megan; Scozzari, Dawn; Van Harn, Meredith; Miller, Daniel; Katramados, Angelos; Hefzy, Hebah; Malik, Shaneela; Marin, Horia (January 2020). "CTA-for-All: Impact of Emergency Computed Tomographic Angiography for All Patients With Stroke Presenting Within 24 Hours of Onset". Stroke. 51 (1): 331–334. doi:10.1161/STROKEAHA.119.027356. ISSN 1524-4628. PMID 31684848. S2CID 207903930.
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