Spen
Spen may refer to:
- SPEN, human gene
- S.P.E.N., Secret sof
- Spen, West Yorkshire, a location in England
- River Spen, river in West Yorkshire, England, the United Kingdom
- SS Spen, British steamship built in 1908
- Spen Whittaker (1871–1910), English football manager
- SP Energy Networks, the energy networks arm of Scottish Power
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