Sergey Piletsky

Sergey Piletsky is a professor of Bioanalytical Chemistry[1] and the Research Director for School of Chemistry, University of Leicester, United Kingdom.[1]

Sergey Piletsky
NationalityBritish
EducationPhD, DSc
Alma materKeiv University Cranfield University
OccupationProfessor
EmployerLeicester University
Known for
  • Biosensors
  • Molecularly imprinted polymers
  • Computational design of molecular imprinting
AwardsRoyal Society Wolfson Research Merit Award

Leverhulme Trust Fellowship

DFG Fellowship Institute of Analytical Chemistry

Award of President of Ukraine

Japan Society for Promotion of Science and Technology Fellowship
Websitehttps://le.ac.uk/people/sergey-piletsky

Education

Sergey graduated from Kiev University,[1] Ukraine, obtaining an MSc in chemistry in 1985 and researched on synthesis of the polymers selective for nucleic acids, for which he was awarded with a PhD in 1991.[1] Cranfield University awarded Sergey with a DSc for his work on Molecularly imprinted polymers for diagnostics applications.[1]

Awards

Sergey is a recipient of Royal Society Wolfson Research Merit Award,[1] Leverhulme Trust Fellowship,[1] DFG Fellowship from the Institute of Analytical Chemistry,[1] Award of President of Ukraine,[1] and Japan Society for Promotion of Science and Technology Fellowship.[1]

Research

Sergey's work in molecular imprinting focuses on: (i) the fundamental study of the recognition properties of molecularly imprinted polymers;[2][3][4][5] (ii) the development of sensors and assays for environmental and clinical analysis;[6][7][8][9] and (iii) the development of molecularly imprinted polymers nanoparticles for theranostic applications.[10][11][12][13]

Sergey introduced computational design into the field of molecular imprinting, by scientifically demonstrating that non-covalent interaction between the template molecule and polymer is through the technique 'bite and switch' where functional groups first non-covalently bond with the binding site, but during the rebinding step, the polymer matrix forms irreversible covalent bonds with the target molecule.[14] A number of research groups around the world follow his idea, for developing functional imprinted polymers for a variety of applications.[15][16][17][18]

Most widely cited journal publications

  • Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009-01-26). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180. doi:10.1016/j.aca.2008.11.010. ISSN 0003-2670. PMID 19110091.
  • Whitcombe, Michael J.; Chianella, Iva; Larcombe, Lee; Piletsky, Sergey A.; Noble, James; Porter, Robert; Horgan, Adrian (2011-02-22). "The rational development of molecularly imprinted polymer-based sensors for protein detection". Chemical Society Reviews. 40 (3): 1547–1571. doi:10.1039/C0CS00049C. hdl:1826/6232. ISSN 1460-4744. PMID 21132204.
  • Bossi, A.; Bonini, F.; Turner, A. P. F.; Piletsky, S. A. (2007-01-15). "Molecularly imprinted polymers for the recognition of proteins: The state of the art". Biosensors and Bioelectronics. 22 (6): 1131–1137. doi:10.1016/j.bios.2006.06.023. ISSN 0956-5663. PMID 16891110.
  • Surface-grafted molecularly imprinted polymers for protein recognition, A Bossi, SA Piletsky, EV Piletska, PG Righetti, APF Turner, Analytical chemistry 73 (21), 5281-5286[19]
  • Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element, Dhana Lakshmi, Alessandra Bossi, Michael J Whitcombe, Iva Chianella, Steven A Fowler, Sreenath Subrahmanyam, Elena V Piletska, Sergey A Piletsky, Analytical Chemistry 81 (9), 3576-3584[20]

Most widely cited books and book chapters

Most widely recognized patents

  • Rationally Designed Selective Binding Polymers (2010), Publication number: 20100009859, Inventors: Sergey A. Piletsky, Olena Piletska, Khalku Karim, Coulton H. Legge, Sreenath Subrahmanyam[22]
  • Electrochemical Sensor (2019) Publication number: 20210239643, Inventors: Sergey Piletsky, Omar Sheej Ahamad, Alvaro Garcia Cruz[23]
  • Polymerisation method, polymers and uses thereof (2006) Publication number: 20060122288, Inventors: Sergey Piletsky, Olena Piletska, Anthony Turner, Khalku Karim, Beining Chen[24]
  • Methods and Kits for determining binding sites (2020) Publication number: 20200033356, Inventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones[25]
  • Photoreactor and Process for Preparing MIP Nanoparticles (2014) Publication number: 20140228472, Inventors: Sergey Piletsky, Olena Piletska, Antonio Guerreiro, Michael Whitcombe, Alessandro Poma[26]

References

  1. "Sergey Piletsky | People | University of Leicester". le.ac.uk. Retrieved 2022-08-16.
  2. Piletsky, Sergey A.; Andersson, Håkan S.; Nicholls, Ian A. (1998). "The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers". Journal of Molecular Recognition. 11 (1–6): 94–97. doi:10.1002/(sici)1099-1352(199812)11:1/6<94::aid-jmr398>3.0.co;2-c. PMID 10076815. S2CID 32111375.
  3. Andersson, Håkan S; Karlsson, Jesper G; Piletsky, Sergey A; Koch-Schmidt, Ann-Christin; Mosbach, Klaus; Nicholls, Ian A (1999). "Study of the nature of recognition in molecularly imprinted polymers, II". Journal of Chromatography A. 848 (1–2): 39–49. doi:10.1016/s0021-9673(99)00483-5. ISSN 0021-9673.
  4. Subrahmanyam, S.; Piletsky, S. A.; Piletska, E. V.; Chen, B.; Day, R.; Turner, A. P. F. (2000). <722::aid-adma722>3.0.co;2-a ""Bite-and-Switch" Approach to Creatine Recognition by Use of Molecularly Imprinted Polymers". Advanced Materials. 12 (10): 722–724. doi:10.1002/(sici)1521-4095(200005)12:10<722::aid-adma722>3.0.co;2-a. ISSN 0935-9648.
  5. Beining Chen, Bentham Science Publisher; Sergey Piletsky, Bentham Science Publisher; Anthony P.F. Turner, Bentham Science Publisher (2002-09-01). "Molecular Recognition: Design of "Keys"". Combinatorial Chemistry & High Throughput Screening. 5 (6): 409–427. doi:10.2174/1386207023330129. ISSN 1386-2073. PMID 12470272.
  6. Subrahmanyam, Sreenath; Piletsky, Sergey A.; Turner, Anthony P. F. (2002-07-19). "Application of Natural Receptors in Sensors and Assays". Analytical Chemistry. 74 (16): 3942–3951. doi:10.1021/ac025673+. ISSN 0003-2700. PMID 12199559.
  7. Piletsky, Sergey A.; Turner, Anthony P.F. (2002), "New Materials Based on Imprinted Polymers and their Application in Optical Sensors", Optical Biosensors, Elsevier, pp. 397–425, doi:10.1016/b978-044450974-1/50013-6, ISBN 9780444509741, retrieved 2022-08-16
  8. Piletsky, Sergey A.; Subrahmanyam, S.; Turner, Anthony P.F. (2001-12-01). "Application of molecularly imprinted polymers in sensors for the environment and biotechnology". Sensor Review. 21 (4): 292–296. doi:10.1108/eum0000000005998. ISSN 0260-2288.
  9. Sergeyeva, Tetyana; Yarynka, Daria; Dubey, Larysa; Dubey, Igor; Piletska, Elena; Linnik, Rostyslav; Antonyuk, Maksym; Ternovska, Tamara; Brovko, Oleksandr; Piletsky, Sergey; El'skaya, Anna (2020-08-01). "Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals". Sensors. 20 (15): 4304. Bibcode:2020Senso..20.4304S. doi:10.3390/s20154304. ISSN 1424-8220. PMC 7435851. PMID 32752255.
  10. Corrigan, Damion K; Salton, Neale A; Preston, Chris; Piletsky, Sergey (2010-08-02). "Towards the development of a rapid, portable, surface enhanced Raman spectroscopy based cleaning verification system for the drug nelarabine". Journal of Pharmacy and Pharmacology. 62 (9): 1195–1200. doi:10.1111/j.2042-7158.2010.01152.x. ISSN 0022-3573. PMID 20796200. S2CID 37284684.
  11. Canfarotta, Francesco; Lezina, Larissa; Guerreiro, António; Czulak, Joanna; Petukhov, Alexey; Daks, Alexandra; Smolinska-Kempisty, Katarzyna; Poma, Alessandro; Piletsky, Sergey; Barlev, Nickolai A. (2018-07-03). "Specific Drug Delivery to Cancer Cells with Double-Imprinted Nanoparticles against Epidermal Growth Factor Receptor". Nano Letters. 18 (8): 4641–4646. Bibcode:2018NanoL..18.4641C. doi:10.1021/acs.nanolett.7b03206. ISSN 1530-6984. PMID 29969563. S2CID 206743515.
  12. Turner, A. P. F.; Piletsky, S. (2005), "Biosensors and Biomimetic Sensors for the Detection of Drugs, Toxins and Biological Agents", Defense against Bioterror, NATO Security through Science Series, Berlin/Heidelberg: Springer-Verlag, pp. 261–272, doi:10.1007/1-4020-3384-2_20, ISBN 1-4020-3386-9, retrieved 2022-08-16
  13. Nicholls, C.; Karim, K.; Piletsky, S.; Saini, S.; Setford, S. (2006). "Displacement imprinted polymer receptor analysis (DIPRA) for chlorophenolic contaminants in drinking water and packaging materials". Biosensors and Bioelectronics. 21 (7): 1171–1177. doi:10.1016/j.bios.2005.05.002. ISSN 0956-5663. PMID 15964753.
  14. Subrahmanyam, Sreenath; Piletsky, Sergey A; Piletska, Elena V; Chen, Beining; Karim, Kal; Turner, Anthony P.F (2001). "'Bite-and-Switch' approach using computationally designed molecularly imprinted polymers for sensing of creatinine11Editors Selection". Biosensors and Bioelectronics. 16 (9–12): 631–637. doi:10.1016/s0956-5663(01)00191-9. ISSN 0956-5663. PMID 11679238.
  15. Marć, Mariusz; Kupka, Teobald; Wieczorek, Piotr Paweł; Namieśnik, Jacek (2018). "Computational modeling of molecularly imprinted polymers as a green approach to the development of novel analytical sorbents". TrAC Trends in Analytical Chemistry. 98: 64–78. doi:10.1016/j.trac.2017.10.020. ISSN 0165-9936.
  16. "Toward Rational Design of Selective Molecularly Imprinted Polymers (MIPs) for Proteins: Computational and Experimental Studies of Acrylamide-Based Polymers for Myoglobin". dx.doi.org. doi:10.1021/acs.jpcb.9b03091.s001. Retrieved 2022-08-16.
  17. Reyes, N B D; Pajarito, B B (2019-10-01). "Computational design of dummy molecularly imprinted polymers via hydrogen bonding investigation for oxytetracycline determination". IOP Conference Series: Materials Science and Engineering. 634 (1): 012035. Bibcode:2019MS&E..634a2035R. doi:10.1088/1757-899x/634/1/012035. ISSN 1757-8981. S2CID 210806505.
  18. Sales, T. A.; Ramalho, T. C. (2020-01-23). "Computational design of synthetic receptors for drug detection: interaction between molecularly imprinted polymers and MDMA (3,4-methylenedioxymethamphetamine)". Theoretical Chemistry Accounts. 139 (2). doi:10.1007/s00214-020-2543-x. ISSN 1432-881X. S2CID 211027995.
  19. Bossi, Alessandra; Piletsky, Sergey A.; Piletska, Elena V.; Righetti, Pier Giorgio; Turner, Anthony P. F. (2001-11-01). "Surface-Grafted Molecularly Imprinted Polymers for Protein Recognition". Analytical Chemistry. 73 (21): 5281–5286. doi:10.1021/ac0006526. ISSN 0003-2700. PMID 11721930.
  20. Lakshmi, Dhana; Bossi, Alessandra; Whitcombe, Michael J.; Chianella, Iva; Fowler, Steven A.; Subrahmanyam, Sreenath; Piletska, Elena V.; Piletsky, Sergey A. (2009-05-01). "Electrochemical Sensor for Catechol and Dopamine Based on a Catalytic Molecularly Imprinted Polymer-Conducting Polymer Hybrid Recognition Element". Analytical Chemistry. 81 (9): 3576–3584. doi:10.1021/ac802536p. ISSN 0003-2700. PMID 19354259.
  21. F., Piletsky, Sergey. Turner, Anthony P. (2006). Molecular imprinting of polymers. Landes Bioscience. ISBN 1-58706-219-4. OCLC 65195271.{{cite book}}: CS1 maint: multiple names: authors list (link)
  22. "US Patent Application for RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS Patent Application (Application #20100009859 issued January 14, 2010) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  23. "US Patent Application for ELECTROCHEMICAL SENSOR Patent Application (Application #20210239643 issued August 5, 2021) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  24. "US Patent Application for Polymerisation method, polymers and uses thereof Patent Application (Application #20060122288 issued June 8, 2006) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  25. "US Patent Application for METHODS AND KITS FOR DETERMINING BINDING SITES Patent Application (Application #20200033356 issued January 30, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  26. "US Patent Application for Photoreactor and Process for Preparing MIP Nanoparticles Patent Application (Application #20140228472 issued August 14, 2014) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.