Sergey Piletsky
Sergey Piletsky is a professor of Bioanalytical Chemistry[1] and the Research Director for School of Chemistry, University of Leicester, United Kingdom.[1]
Sergey Piletsky | |
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Nationality | British |
Education | PhD, DSc |
Alma mater | Keiv University Cranfield University |
Occupation | Professor |
Employer | Leicester University |
Known for |
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Awards | Royal Society Wolfson Research Merit Award
Leverhulme Trust Fellowship DFG Fellowship Institute of Analytical Chemistry Award of President of Ukraine Japan Society for Promotion of Science and Technology Fellowship |
Website | https://le.ac.uk/people/sergey-piletsky |
Education
Sergey graduated from Kiev University,[1] Ukraine, obtaining an MSc in chemistry in 1985 and researched on synthesis of the polymers selective for nucleic acids, for which he was awarded with a PhD in 1991.[1] Cranfield University awarded Sergey with a DSc for his work on Molecularly imprinted polymers for diagnostics applications.[1]
Awards
Sergey is a recipient of Royal Society Wolfson Research Merit Award,[1] Leverhulme Trust Fellowship,[1] DFG Fellowship from the Institute of Analytical Chemistry,[1] Award of President of Ukraine,[1] and Japan Society for Promotion of Science and Technology Fellowship.[1]
Research
Sergey's work in molecular imprinting focuses on: (i) the fundamental study of the recognition properties of molecularly imprinted polymers;[2][3][4][5] (ii) the development of sensors and assays for environmental and clinical analysis;[6][7][8][9] and (iii) the development of molecularly imprinted polymers nanoparticles for theranostic applications.[10][11][12][13]
Sergey introduced computational design into the field of molecular imprinting, by scientifically demonstrating that non-covalent interaction between the template molecule and polymer is through the technique 'bite and switch' where functional groups first non-covalently bond with the binding site, but during the rebinding step, the polymer matrix forms irreversible covalent bonds with the target molecule.[14] A number of research groups around the world follow his idea, for developing functional imprinted polymers for a variety of applications.[15][16][17][18]
Most widely cited journal publications
- Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009-01-26). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180. doi:10.1016/j.aca.2008.11.010. ISSN 0003-2670. PMID 19110091.
- Whitcombe, Michael J.; Chianella, Iva; Larcombe, Lee; Piletsky, Sergey A.; Noble, James; Porter, Robert; Horgan, Adrian (2011-02-22). "The rational development of molecularly imprinted polymer-based sensors for protein detection". Chemical Society Reviews. 40 (3): 1547–1571. doi:10.1039/C0CS00049C. hdl:1826/6232. ISSN 1460-4744. PMID 21132204.
- Bossi, A.; Bonini, F.; Turner, A. P. F.; Piletsky, S. A. (2007-01-15). "Molecularly imprinted polymers for the recognition of proteins: The state of the art". Biosensors and Bioelectronics. 22 (6): 1131–1137. doi:10.1016/j.bios.2006.06.023. ISSN 0956-5663. PMID 16891110.
- Surface-grafted molecularly imprinted polymers for protein recognition, A Bossi, SA Piletsky, EV Piletska, PG Righetti, APF Turner, Analytical chemistry 73 (21), 5281-5286[19]
- Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element, Dhana Lakshmi, Alessandra Bossi, Michael J Whitcombe, Iva Chianella, Steven A Fowler, Sreenath Subrahmanyam, Elena V Piletska, Sergey A Piletsky, Analytical Chemistry 81 (9), 3576-3584[20]
Most widely cited books and book chapters
- Subrahmanyam, Sreenath; Karim, Kal; Piletsky, Sergey A. (2012), Piletsky, Sergey A.; Whitcombe, Michael J. (eds.), "Computational Approaches in the Design of Synthetic Receptors", Designing Receptors for the Next Generation of Biosensors, Berlin, Heidelberg: Springer Berlin Heidelberg, vol. 12, pp. 131–165, doi:10.1007/5346_2012_22, ISBN 978-3-642-32328-7, retrieved 2022-08-17
- Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009), "Computational Design of Molecularly Imprinted Polymers", Combinatorial Methods for Chemical and Biological Sensors, New York, NY: Springer New York, pp. 135–172, Bibcode:2009cmcb.book..135S, doi:10.1007/978-0-387-73713-3_6, ISBN 978-0-387-73712-6, retrieved 2022-08-16
- Poma, Alessandro; Whitcombe, Michael; Piletsky, Sergey (2012), "Plastic Antibodies", Springer Series on Chemical Sensors and Biosensors, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 105–129, doi:10.1007/5346_2012_24, ISBN 978-3-642-32328-7, retrieved 2022-08-16
- Rouillon, Régis; Piletsky, Sergey A.; Breton, Florent; Piletska, Elena V.; Carpentier, Robert (2006), Giardi, Maria Teresa; Piletska, Elena V. (eds.), "Photosystem II Biosensors for Heavy Metals Monitoring", Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices, Boston, MA: Springer US, pp. 166–174, doi:10.1007/978-0-387-36672-2_15, ISBN 978-0-387-36672-2, retrieved 2022-08-17
- Piletsky S.A., Turner A.P.F. (2006). New generation of chemical sensors based on molecularly imprinted polymers, in: Molecular imprinting of polymers, S. Piletsky and A.P.F. Turner (eds.), Landes Bioscience, Georgetown, TX, USA[21]
Most widely recognized patents
- Rationally Designed Selective Binding Polymers (2010), Publication number: 20100009859, Inventors: Sergey A. Piletsky, Olena Piletska, Khalku Karim, Coulton H. Legge, Sreenath Subrahmanyam[22]
- Electrochemical Sensor (2019) Publication number: 20210239643, Inventors: Sergey Piletsky, Omar Sheej Ahamad, Alvaro Garcia Cruz[23]
- Polymerisation method, polymers and uses thereof (2006) Publication number: 20060122288, Inventors: Sergey Piletsky, Olena Piletska, Anthony Turner, Khalku Karim, Beining Chen[24]
- Methods and Kits for determining binding sites (2020) Publication number: 20200033356, Inventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones[25]
- Photoreactor and Process for Preparing MIP Nanoparticles (2014) Publication number: 20140228472, Inventors: Sergey Piletsky, Olena Piletska, Antonio Guerreiro, Michael Whitcombe, Alessandro Poma[26]
References
- "Sergey Piletsky | People | University of Leicester". le.ac.uk. Retrieved 2022-08-16.
- Piletsky, Sergey A.; Andersson, Håkan S.; Nicholls, Ian A. (1998). "The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers". Journal of Molecular Recognition. 11 (1–6): 94–97. doi:10.1002/(sici)1099-1352(199812)11:1/6<94::aid-jmr398>3.0.co;2-c. PMID 10076815. S2CID 32111375.
- Andersson, Håkan S; Karlsson, Jesper G; Piletsky, Sergey A; Koch-Schmidt, Ann-Christin; Mosbach, Klaus; Nicholls, Ian A (1999). "Study of the nature of recognition in molecularly imprinted polymers, II". Journal of Chromatography A. 848 (1–2): 39–49. doi:10.1016/s0021-9673(99)00483-5. ISSN 0021-9673.
- Subrahmanyam, S.; Piletsky, S. A.; Piletska, E. V.; Chen, B.; Day, R.; Turner, A. P. F. (2000). <722::aid-adma722>3.0.co;2-a ""Bite-and-Switch" Approach to Creatine Recognition by Use of Molecularly Imprinted Polymers". Advanced Materials. 12 (10): 722–724. doi:10.1002/(sici)1521-4095(200005)12:10<722::aid-adma722>3.0.co;2-a. ISSN 0935-9648.
- Beining Chen, Bentham Science Publisher; Sergey Piletsky, Bentham Science Publisher; Anthony P.F. Turner, Bentham Science Publisher (2002-09-01). "Molecular Recognition: Design of "Keys"". Combinatorial Chemistry & High Throughput Screening. 5 (6): 409–427. doi:10.2174/1386207023330129. ISSN 1386-2073. PMID 12470272.
- Subrahmanyam, Sreenath; Piletsky, Sergey A.; Turner, Anthony P. F. (2002-07-19). "Application of Natural Receptors in Sensors and Assays". Analytical Chemistry. 74 (16): 3942–3951. doi:10.1021/ac025673+. ISSN 0003-2700. PMID 12199559.
- Piletsky, Sergey A.; Turner, Anthony P.F. (2002), "New Materials Based on Imprinted Polymers and their Application in Optical Sensors", Optical Biosensors, Elsevier, pp. 397–425, doi:10.1016/b978-044450974-1/50013-6, ISBN 9780444509741, retrieved 2022-08-16
- Piletsky, Sergey A.; Subrahmanyam, S.; Turner, Anthony P.F. (2001-12-01). "Application of molecularly imprinted polymers in sensors for the environment and biotechnology". Sensor Review. 21 (4): 292–296. doi:10.1108/eum0000000005998. ISSN 0260-2288.
- Sergeyeva, Tetyana; Yarynka, Daria; Dubey, Larysa; Dubey, Igor; Piletska, Elena; Linnik, Rostyslav; Antonyuk, Maksym; Ternovska, Tamara; Brovko, Oleksandr; Piletsky, Sergey; El'skaya, Anna (2020-08-01). "Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals". Sensors. 20 (15): 4304. Bibcode:2020Senso..20.4304S. doi:10.3390/s20154304. ISSN 1424-8220. PMC 7435851. PMID 32752255.
- Corrigan, Damion K; Salton, Neale A; Preston, Chris; Piletsky, Sergey (2010-08-02). "Towards the development of a rapid, portable, surface enhanced Raman spectroscopy based cleaning verification system for the drug nelarabine". Journal of Pharmacy and Pharmacology. 62 (9): 1195–1200. doi:10.1111/j.2042-7158.2010.01152.x. ISSN 0022-3573. PMID 20796200. S2CID 37284684.
- Canfarotta, Francesco; Lezina, Larissa; Guerreiro, António; Czulak, Joanna; Petukhov, Alexey; Daks, Alexandra; Smolinska-Kempisty, Katarzyna; Poma, Alessandro; Piletsky, Sergey; Barlev, Nickolai A. (2018-07-03). "Specific Drug Delivery to Cancer Cells with Double-Imprinted Nanoparticles against Epidermal Growth Factor Receptor". Nano Letters. 18 (8): 4641–4646. Bibcode:2018NanoL..18.4641C. doi:10.1021/acs.nanolett.7b03206. ISSN 1530-6984. PMID 29969563. S2CID 206743515.
- Turner, A. P. F.; Piletsky, S. (2005), "Biosensors and Biomimetic Sensors for the Detection of Drugs, Toxins and Biological Agents", Defense against Bioterror, NATO Security through Science Series, Berlin/Heidelberg: Springer-Verlag, pp. 261–272, doi:10.1007/1-4020-3384-2_20, ISBN 1-4020-3386-9, retrieved 2022-08-16
- Nicholls, C.; Karim, K.; Piletsky, S.; Saini, S.; Setford, S. (2006). "Displacement imprinted polymer receptor analysis (DIPRA) for chlorophenolic contaminants in drinking water and packaging materials". Biosensors and Bioelectronics. 21 (7): 1171–1177. doi:10.1016/j.bios.2005.05.002. ISSN 0956-5663. PMID 15964753.
- Subrahmanyam, Sreenath; Piletsky, Sergey A; Piletska, Elena V; Chen, Beining; Karim, Kal; Turner, Anthony P.F (2001). "'Bite-and-Switch' approach using computationally designed molecularly imprinted polymers for sensing of creatinine11Editors Selection". Biosensors and Bioelectronics. 16 (9–12): 631–637. doi:10.1016/s0956-5663(01)00191-9. ISSN 0956-5663. PMID 11679238.
- Marć, Mariusz; Kupka, Teobald; Wieczorek, Piotr Paweł; Namieśnik, Jacek (2018). "Computational modeling of molecularly imprinted polymers as a green approach to the development of novel analytical sorbents". TrAC Trends in Analytical Chemistry. 98: 64–78. doi:10.1016/j.trac.2017.10.020. ISSN 0165-9936.
- "Toward Rational Design of Selective Molecularly Imprinted Polymers (MIPs) for Proteins: Computational and Experimental Studies of Acrylamide-Based Polymers for Myoglobin". dx.doi.org. doi:10.1021/acs.jpcb.9b03091.s001. Retrieved 2022-08-16.
- Reyes, N B D; Pajarito, B B (2019-10-01). "Computational design of dummy molecularly imprinted polymers via hydrogen bonding investigation for oxytetracycline determination". IOP Conference Series: Materials Science and Engineering. 634 (1): 012035. Bibcode:2019MS&E..634a2035R. doi:10.1088/1757-899x/634/1/012035. ISSN 1757-8981. S2CID 210806505.
- Sales, T. A.; Ramalho, T. C. (2020-01-23). "Computational design of synthetic receptors for drug detection: interaction between molecularly imprinted polymers and MDMA (3,4-methylenedioxymethamphetamine)". Theoretical Chemistry Accounts. 139 (2). doi:10.1007/s00214-020-2543-x. ISSN 1432-881X. S2CID 211027995.
- Bossi, Alessandra; Piletsky, Sergey A.; Piletska, Elena V.; Righetti, Pier Giorgio; Turner, Anthony P. F. (2001-11-01). "Surface-Grafted Molecularly Imprinted Polymers for Protein Recognition". Analytical Chemistry. 73 (21): 5281–5286. doi:10.1021/ac0006526. ISSN 0003-2700. PMID 11721930.
- Lakshmi, Dhana; Bossi, Alessandra; Whitcombe, Michael J.; Chianella, Iva; Fowler, Steven A.; Subrahmanyam, Sreenath; Piletska, Elena V.; Piletsky, Sergey A. (2009-05-01). "Electrochemical Sensor for Catechol and Dopamine Based on a Catalytic Molecularly Imprinted Polymer-Conducting Polymer Hybrid Recognition Element". Analytical Chemistry. 81 (9): 3576–3584. doi:10.1021/ac802536p. ISSN 0003-2700. PMID 19354259.
- F., Piletsky, Sergey. Turner, Anthony P. (2006). Molecular imprinting of polymers. Landes Bioscience. ISBN 1-58706-219-4. OCLC 65195271.
{{cite book}}
: CS1 maint: multiple names: authors list (link) - "US Patent Application for RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS Patent Application (Application #20100009859 issued January 14, 2010) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
- "US Patent Application for ELECTROCHEMICAL SENSOR Patent Application (Application #20210239643 issued August 5, 2021) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
- "US Patent Application for Polymerisation method, polymers and uses thereof Patent Application (Application #20060122288 issued June 8, 2006) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
- "US Patent Application for METHODS AND KITS FOR DETERMINING BINDING SITES Patent Application (Application #20200033356 issued January 30, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
- "US Patent Application for Photoreactor and Process for Preparing MIP Nanoparticles Patent Application (Application #20140228472 issued August 14, 2014) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
External links
- Sergey Piletsky publications indexed by Google Scholar