Sebox homeobox

SEBOX
Identifiers
Aliases	SEBOX, OG-9, OG9, OG9X, Sebox homeobox
External IDs	OMIM: 610975 MGI: 108012 HomoloGene: 32052 GeneCards: SEBOX
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	28,365,199 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	78,395,907 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; skeletal muscle tissue; ; blood; ; monocyte; ; duodenum; ; right adrenal gland; ; prefrontal cortex; ; smooth muscle tissue; ; islet of Langerhans; ; placenta;
	Top expressed in
	secondary oocyte; ; morula; ; submandibular gland; ; urethra; ; ovarian follicle; ; granular layer; ; Region IV of hippocampus proper; ; triceps brachii muscle; ; lip; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; molecular function;
Cellular component	nucleus; cellular component;
Biological process	multicellular organism development; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; biological process; embryo development ending in birth or egg hatching; oogenesis;
	Sources:Amigo / QuickGO
Orthologs
	645832
	18292
	ENSG00000274529
	ENSMUSG00000001103
	Q9HB31
	P70368
	NM_001083896; NM_001080837
	NM_008759
	NP_001074306
	NP_032785
	Wikidata
View/Edit Human	View/Edit Mouse

SEBOX homeobox is a protein that in humans is encoded by the SEBOX gene.[5] Sebox homeobox has a 92% similarity to genes found within rhesus macaque, or the rhesus monkey. It is thought that this is what causes the reddened glutius maximus coloring. If the protein is turned on within a person, it may cause discoloring in the human rear.

Function

Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development.[6]

References

GRCh38: Ensembl release 89: ENSG00000274529 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001103 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SEBOX homeobox".
Cinquanta M, Rovescalli AC, Kozak CA, Nirenberg M (2000). "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8904–9. Bibcode:2000PNAS...97.8904C. doi:10.1073/pnas.97.16.8904. PMC 16794. PMID 10922053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000274529 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001103 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SEBOX homeobox".

[pmid10922053-6] Cinquanta M, Rovescalli AC, Kozak CA, Nirenberg M (2000). "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8904–9. Bibcode:2000PNAS...97.8904C. doi:10.1073/pnas.97.16.8904. PMC 16794. PMID 10922053.