Synaptojanin 1

SYNJ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W80, 2DNR, 2VJ0
Identifiers
Aliases	SYNJ1, INPP5G, PARK20, synaptojanin 1, EIEE53, DEE53
External IDs	OMIM: 604297 MGI: 1354961 HomoloGene: 48252 GeneCards: SYNJ1
Gene location (Human)
Chr.	Chromosome 21 (human)[1]
End	32,728,040 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	90,808,196 bp[2]
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; pons; ; middle temporal gyrus; ; superior frontal gyrus; ; endothelial cell; ; postcentral gyrus; ; superior vestibular nucleus; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; entorhinal cortex;
	Top expressed in
	pontine nuclei; ; subiculum; ; Region I of hippocampus proper; ; prefrontal cortex; ; medial vestibular nucleus; ; temporal lobe; ; amygdala; ; medial dorsal nucleus; ; facial motor nucleus; ; habenula;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA binding; nucleic acid binding; phosphoric ester hydrolase activity; hydrolase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol phosphate 4-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; protein binding; SH3 domain binding;
Cellular component	cytoplasm; membrane coat; vesicle membrane; presynapse; synaptic membrane; clathrin coat of coated pit; terminal bouton; microtubule; perinuclear region of cytoplasm; cytosol; neuron projection; postsynapse;
Biological process	endocytosis; phosphatidylinositol metabolic process; inositol phosphate metabolic process; learning; synaptic vesicle uncoating; synaptic vesicle priming; phosphatidylinositol biosynthetic process; synaptic vesicle transport; neurotransmitter transport; inositol phosphate dephosphorylation; phosphatidylinositol dephosphorylation; positive regulation of endosome organization; phosphatidylinositol-3-phosphate biosynthetic process; membrane organization; synaptic vesicle endocytosis; brain development; positive regulation of gliogenesis; response to retinoic acid; response to cytokine; positive regulation of receptor-mediated endocytosis; postsynaptic neurotransmitter receptor internalization;
	Sources:Amigo / QuickGO
Orthologs
	8867
	104015
	ENSG00000159082
	ENSMUSG00000022973
	O43426
	Q8CHC4
	NM_203446; NM_001160302; NM_001160306; NM_003895
	NM_001045515; NM_001164483
	NP_001153774; NP_001153778; NP_003886; NP_982271
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptojanin 1 is a protein that in humans is encoded by the SYNJ1 gene. [5]

Function

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

References

GRCh38: Ensembl release 89: ENSG00000159082 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022973 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Synaptojanin 1". Retrieved 2016-03-13.

Synaptojanin 1

Function

References

Further reading