SNAPC4

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene.[5][6]

SNAPC4
Identifiers
AliasesSNAPC4, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
External IDsOMIM: 602777 MGI: 2443935 HomoloGene: 2321 GeneCards: SNAPC4
Orthologs
SpeciesHumanMouse
Entrez

6621

227644

Ensembl

ENSG00000165684

ENSMUSG00000036281

UniProt

Q5SXM2

Q8BP86

RefSeq (mRNA)

NM_003086
NM_001394201
NM_001394202
NM_001394203

NM_001290419
NM_172339

RefSeq (protein)

NP_003077

Location (UCSC)Chr 9: 136.38 – 136.4 MbChr 2: 26.25 – 26.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of SNAPC4 function. A conditional knockout mouse line, called Snapc4tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at weaning. The remaining tests were carried out on adult heterozygous mutant animals and no further abnormalities were observed.[9]

Interactions

SNAPC4 has been shown to interact with SNAPC1,[17] POU2F1[5][18] and SNAPC2.[5][17]

References
  1. GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
  6. "Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa".
  7. "Salmonella infection data for Snapc4". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Snapc4". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  17. Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
  18. Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. doi:10.1107/S0907444901021461. PMID 11856838.

Further reading
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