SLC35F1
Solute carrier family 35, member F1 is a protein that in humans is encoded by the SLC35F1 gene.[1] The gene is also known as C6orf169 or dJ230I3.1.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Tail epidermis wholemount | Normal |
| Skin Histopathology | Normal |
| Brain histopathology | Normal |
| Eye Histopathology | Normal |
| Salmonella infection | Normal[2] |
| Citrobacter infection | Normal[3] |
| All tests and analysis from[4][5] |
Model organisms have been used in the study of SLC35F1 function. A conditional knockout mouse line, called Slc35f1tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[4]
References
- "Solute carrier family 35, member F1". Retrieved 2011-12-04.
- "Salmonella infection data for Slc35f1". Wellcome Trust Sanger Institute.
- "Citrobacter infection data for Slc35f1". Wellcome Trust Sanger Institute.
- Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248): 0. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
- Mouse Resources Portal, Wellcome Trust Sanger Institute.
- "International Knockout Mouse Consortium".
- "Mouse Genome Informatics".
- Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- Collins FS; Rossant J; Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
- van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
Further reading
- Sotoodehnia, N.; Isaacs, A.; De Bakker, P. I. W.; Dörr, M.; Newton-Cheh, C.; Nolte, I. M.; Van Der Harst, P.; Müller, M.; Eijgelsheim, M.; Alonso, A.; Hicks, A. A.; Padmanabhan, S.; Hayward, C.; Smith, A. V.; Polasek, O.; Giovannone, S.; Fu, J.; Magnani, J. W.; Marciante, K. D.; Pfeufer, A.; Gharib, S. A.; Teumer, A.; Li, M.; Bis, J. C.; Rivadeneira, F.; Aspelund, T.; Köttgen, A.; Johnson, T.; Rice, K.; et al. (2010). "Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction". Nature Genetics. 42 (12): 1068–1076. doi:10.1038/ng.716. PMC 3338195. PMID 21076409.
- Eijgelsheim, M.; Newton-Cheh, C.; Sotoodehnia, N.; De Bakker, P. I. W.; Müller, M.; Morrison, A. C.; Smith, A. V.; Isaacs, A.; Sanna, S.; Dörr, M.; Navarro, P.; Fuchsberger, C.; Nolte, I. M.; De Geus, E. J. C.; Estrada, K.; Hwang, S. -J.; Bis, J. C.; Rückert, I. -M.; Alonso, A.; Launer, L. J.; Hottenga, J. J.; Rivadeneira, F.; Noseworthy, P. A.; Rice, K. M.; Perz, S.; Arking, D. E.; Spector, T. D.; Kors, J. A.; Aulchenko, Y. S.; Tarasov, K. V. (2010). "Genome-wide association analysis identifies multiple loci related to resting heart rate". Human Molecular Genetics. 19 (19): 3885–3894. doi:10.1093/hmg/ddq303. PMC 3657480. PMID 20639392.
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