SAT2

SAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BEI, 2Q4V
Identifiers
Aliases	SAT2, Sspermidine/spermine N1-acetyltransferase family member 2, SSAT-2
External IDs	OMIM: 611463 MGI: 1916465 HomoloGene: 44215 GeneCards: SAT2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	7,627,876 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	69,514,696 bp[2]
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; duodenum; ; kidney; ; anterior pituitary; ; body of pancreas; ; Brodmann area 9; ; renal medulla; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	otolith organ; ; utricle; ; retinal pigment epithelium; ; proximal tubule; ; internal carotid artery; ; external carotid artery; ; pineal gland; ; hand; ; ovary; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; N-acetyltransferase activity; acyltransferase activity; diamine N-acetyltransferase activity; protein binding; identical protein binding; spermidine binding;
Cellular component	cytoplasm; extracellular exosome;
Biological process	putrescine acetylation; spermine acetylation; nor-spermidine metabolic process; spermidine acetylation; putrescine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	112483
	69215
	ENSG00000141504
	ENSMUSG00000069835
	Q96F10
	Q6P8J2
	NM_133491; NM_001320845; NM_001320846; NM_001320847
	NM_026991; NM_001356468; NM_001356469
	NP_001307774; NP_001307775; NP_001307776; NP_597998
	NP_081267; NP_001343397; NP_001343398
	Wikidata
View/Edit Human	View/Edit Mouse

Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[5][6][7] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[8]

References

GRCh38: Ensembl release 89: ENSG00000141504 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000069835 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.
Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.
"Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.

Baek JH, Liu YV, McDonald KR, et al. (2008). "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha". J. Biol. Chem. 282 (46): 33358–66. doi:10.1074/jbc.M705627200. PMID 17875644.
Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR". Mol. Cell. Biochem. 298 (1–2): 59–68. doi:10.1007/s11010-006-9350-0. hdl:11383/1672116. PMID 17119850. S2CID 29889795.
Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006). "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins. 64 (1): 288–93. doi:10.1002/prot.20967. PMID 16596569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen Y, Vujcic S, Liang P, et al. (2003). "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase". Biochem. J. 373 (Pt 3): 661–7. doi:10.1042/BJ20030734. PMC 1223561. PMID 12803540.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141504 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069835 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15283699-5] Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.

[pmid17558023-6] Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.

[entrez-7] "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".

[pmid18832333-8] Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.

SAT2

References

Further reading