Ruth L. Kirschstein

Ruth Lillian Kirschstein (12 October 1926 – 6 October 2009) was an American pathologist and science administrator at the National Institutes of Health (NIH). Kirschstein served as director of the National Institute of General Medical Sciences, deputy director of NIH in the 1990s, and acting director of the NIH in 1993 and 2000-2002.[1]

Ruth L. Kirschstein
Born(1926-10-12)12 October 1926
Brooklyn, New York
Died6 October 2009(2009-10-06) (aged 82)
Bethesda, Maryland
Alma materLong Island University (BA)
Tulane University School of Medicine (MD)
Known forPolio vaccine safety research First woman appointed director of an NIH Institute
SpouseAlan S. Rabson
ChildrenArnold B. Rabson
AwardsElection to the Institute of Medicine and the American Academy of Arts and Sciences, U. S. Public Health Service (PHS) Superior Service Award (1978), the Presidential Meritorious Executive Rank Award (1980), PHS Special Recognition Award (1985), Presidential Distinguished Executive Rank Award (the highest honor for a career civil servant) (1985), and the Women of Achievement Award from the Jewish Anti-Defamation League (2000)
Scientific career
FieldsPathology, Government Administration

She was a fellow of the American Academy of Arts and Sciences and a member of the Institute of Medicine. In 2002, Congress renamed the NIH graduate student fellowship program to the Ruth L. Kirschstein National Research Service Award in honor of Kirschstein's work at the NIH.[2]

Although she had trained as a classical pianist, she pursued medicine, graduating in 1947 from Long Island University and earning a Doctor of Medicine medical degree from Tulane University in 1951.[1] She interned in medicine and surgery at Kings County hospital and completed medical residencies in pathology at Providence Hospital in Detroit, Tulane University Hospital, and the Clinical Center at the NIH.[3]

Biography

Kirschstein was born to a family of Russian Jewish descent in Brooklyn, New York in 1926.[4][5][6] Although she had trained as a classical pianist, she pursued medicine, graduating in 1947 from Long Island University and earning a medical degree from Tulane University in 1951.[1] She interned in medicine and surgery at Kings County hospital and completed medical residencies in pathology at Providence Hospital in Detroit, Tulane University Hospital, and the Clinical Center at the NIH.[3]

Family

She was married for 59 years to Alan S. Rabson, a pathologist and a deputy director of the National Cancer Institute.[1][7]

Kirschstein's only child, Arnold B. Rabson, was born in 1955, the year she and her husband arrived at the NIH.[8]

Research

Kirschstein joined NIH in 1955. She studied clinical pathology, laboratory medicine, virally-induced cancer and developed the safety test for the polio vaccines following the 1955 Cutter Incident, in addition to working on the safety of the measles vaccine.[1][2]

In 1972, Kirschstein became deputy director of the Division of Biologics Standards, a research division that was transferred from NIH to the Food and Drug Administration, where she investigated the safety of the artificial sweetener cyclamate. When she returned to the NIH in 1974, Kirschstein became the first woman to direct an institute when she was appointed the director of the National Institute of General Medical Sciences (NIGMS).[1] At NIGMS, she raised the profile of the institute, persuading Congress to dramatically increase funding of basic medical science research. She also championed research training support, particularly for under-represented minorities, work that was recognized by the Congressionally-mandated renaming of the National Research Service Awards, as the Ruth L. Kirschstein National Research Service Awards. Kirschstein served as Deputy Director of the NIH under Dr. Harold Varmus, from 1993 to 1999. She served as Acting Director of the National Institutes of Health on two occasions, in 1993, and again from 2000-2002.

Awards

She received honorary degrees from the University of Rochester School of Medicine, Long Island University, Atlanta University, Medical College of Ohio, Brown University, Tulane University, and Mount Sinai School of Medicine.[3]

Among the awards received by Kirschstein are the Georgeanna Seegar Jones Women's Health Lifetime Achievement Award, the Federation of American Societies for Experimental Biology's Public Service Award, the American Medical Association's Dr. Nathan Davis Award, the Harvey Wiley FDA Special Citation, Presidential Rank Award of Distinguished Executive (the country's highest civil service honor), the PHS Equal Opportunity Achievement Award, the Alice C. Evans Award, and superior service awards from the Department of Health, Education and Welfare and the United States Public Health Service.[1][3] She was an elected member of the Institute of Medicine (National Academy of Medicine).

References
  1. "Pathologist Helped Ensure Vaccines' Safety", October 17, 2009, Washington Post
  2. "Taken for Granted: NIH's Dr. Ruth" by Beryl Lieff Benderly, Science doi:10.1126/science.caredit.a0900150
  3. Ruth L. Kirschstein, M.D., Maryland Women Hall of Fame
  4. "Always There: The Remarkable Life of Ruth Lillian Kirschstein, M.D." National Institutes of Health. October 15, 2015. Retrieved July 22, 2018.
  5. Hollenbach, Andrew D. (2018). A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant. Academic Press. p. 1. ISBN 9780128153376.
  6. Davis, Alison (2011). Always There: The Remarkable Life of Ruth L. Kirschstein, M.D. p. 6.
  7. " Ruth Kirschstein and Alan Rabson", Science 15 June 2001: Vol. 292. no. 5524, pg. 1989 doi:10.1126/science.292.5524.1989
  8. Davis, Alison. Always There. NIH. ISBN 978-0-9797540-4-3.
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