40S ribosomal protein S5

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.[5][6][7]

RPS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC,%%s4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5A2Q, 4V6X, 4UJD, 3J7P, 5AJ0, 4KZZ, 4UG0, 4UJE, 4UJC, 5FLX
Identifiers
Aliases	RPS5, S5, ribosomal protein S5
External IDs	OMIM: 603630 MGI: 1097682 HomoloGene: 783 GeneCards: RPS5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 58,386,400 bp[1] End 58,394,806 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 12,656,217 bp[2] End 12,660,613 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva cancellous bone human penis cavity of mouth superficial temporal artery right uterine tube skin of abdomen nipple caput epididymis body of pancreas Top expressed in maxillary prominence internal carotid artery somite medial ganglionic eminence external carotid artery cervix molar abdominal wall dermis endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding rRNA binding Cellular component cytosol ribosome membrane focal adhesion small ribosomal subunit extracellular exosome extracellular matrix nucleoplasm cytosolic small ribosomal subunit ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation regulation of translational fidelity nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis ribosomal small subunit assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6193 20103 Ensembl ENSG00000083845 ENSMUSG00000012848 UniProt P46782 P97461 RefSeq (mRNA) NM_001009 NM_009095 RefSeq (protein) NP_001000 NP_001000.2 NP_033121 Location (UCSC) Chr 19: 58.39 – 58.39 Mb Chr 7: 12.66 – 12.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, in eukaryotes, consist of a small 40S subunit and a large 60S subunit (whereas prokaryotic ribosomes are 70 Svedberg units, composed of 50S and 30S subunits). They are located in the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the eukaryotic 40S subunit. The protein belongs to the S7P family of ribosomal proteins. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]