RNF135
RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.[5][6][7]
| RNF135 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | RNF135, MMFD, REUL, Riplet, L13, ring finger protein 135 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611358 MGI: 1919206 HomoloGene: 12427 GeneCards: RNF135 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]
References
- GRCh38: Ensembl release 89: ENSG00000181481 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000020707 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.
- Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.
- "Entrez Gene: RNF135 ring finger protein 135".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–20. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.
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