Polypeptide N-acetylgalactosaminyltransferase
In enzymology, a polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.41) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-galactosamine + polypeptide UDP + N-acetyl-D-galactosaminyl-polypeptide
| polypeptide N-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.41 | ||||||||
| CAS no. | 9075-15-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and calcium.
Nomenclature
The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include:
- protein-UDP acetylgalactosaminyltransferase,
- UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase,
- UDP-N-acetylgalactosamine:kappa-casein polypeptide,
- N-acetylgalactosaminyltransferase,
- uridine diphosphoacetylgalactosamine-glycoprotein,
- acetylgalactosaminyltransferase,
- glycoprotein acetylgalactosaminyltransferase,
- polypeptide-N-acetylgalactosamine transferase,
- UDP-acetylgalactosamine-glycoprotein,
- acetylgalactosaminyltransferase,
- UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase,
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase,
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide,
- N-acetylgalactosaminyltransferase,
- UDP-N-acetylgalactosamine-glycoprotein,
- N-acetylgalactosaminyltransferase,
- UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase,
- UDP-N-acetylgalactosamine:polypeptide,
- N-acetylgalactosaminyltransferase, and
- UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase.
References
- Sugiura M, Kawasaki T, Yamashina I (1982). "Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66". J. Biol. Chem. 257 (16): 9501–7. PMID 6809738.
- Takeuchi M, Yoshikawa M, Sasaki R, Chiba H (1985). "Purification and characterization of UDP-N-acetylgalactosamine-kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow". Agric. Biol. Chem. 49 (4): 1059–1069. doi:10.1271/bbb1961.49.1059.
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