Polyestradiol phosphate/medroxyprogesterone acetate

Polyestradiol phosphate/medroxyprogesterone acetate (PEP/MPA) is a combination of polyestradiol phosphate (PEP), an estrogen, and medroxyprogesterone acetate (MPA), a progestin, which was studied in the 1960s as a long-lasting combined injectable contraceptive for women but was never marketed.[1][2][3] It was administered by intramuscular injection once every 3 months and contained 40 mg PEP and 150 mg MPA.[1][2][3] The combination was studied in a sample of 99 premenopausal women and was found to be effective in preventing pregnancy, but caused menstrual irregularities similar to those of MPA alone as a progestogen-only injectable contraceptive.[1][2][3] PEP was included in the formulation to prevent estrogen deficiency and reduce menstrual abnormalities caused by MPA during long-term contraceptive therapy.[2]

Polyestradiol phosphate /
medroxyprogesterone acetate

Polyestradiol phosphate (top) and medroxyprogesterone acetate (bottom)
Combination of
Polyestradiol phosphate	Estrogen
Medroxyprogesterone acetate	Progestogen
Clinical data
Other names	PEP/MPA
Routes of administration	Intramuscular injection