Picayune (disambiguation)
Picayune is an obsolete term for a coin of small value. Its meaning has been extended to the figurative sense of "trivial" or "of little value".

Look up picayune in Wiktionary, the free dictionary.
Picayune may also refer to:
- The Times-Picayune, a daily newspaper published in New Orleans, Louisiana, United States
- The Bloom Picayune, a fictional newspaper appearing in the Bloom County cartoon strip
- The Pickax Picayune, a fictional newspaper appearing in the The Cat Who... mystery novels
- Picayune, Mississippi, a city in the southern United States
- Picayune station, an Amtrak station in Picayune, Mississippi
- Picayune Creek, a river in Iowa
- Picayune Strand State Forest, a protected area near Naples, Florida, United States
- John "Picayune" Butler, an influential black entertainer who lived in 19th-century New Orleans
- Picayune cigarettes, a strong-tasting now-defunct brand previously marketed by Liggett & Myers Tobacco Company
- Picayune Rancheria of Chukchansi Indians, the home of a federally recognized tribe of indigenous people of California
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