PRAM1

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.[5][6][7]

PRAM1
Identifiers
AliasesPRAM1, PML-RAR, PRAM-1, PML-RARA regulated adaptor molecule 1
External IDsOMIM: 606466 MGI: 3576625 HomoloGene: 12963 GeneCards: PRAM1
Orthologs
SpeciesHumanMouse
Entrez

84106

378460

Ensembl

ENSG00000133246

ENSMUSG00000032739

UniProt

Q96QH2

Q6BCL1

RefSeq (mRNA)

NM_032152

NM_001002842

RefSeq (protein)

NP_115528

NP_001002842

Location (UCSC)Chr 19: 8.49 – 8.5 MbChr 17: 33.86 – 33.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).[7]

Interactions

PRAM1 has been shown to interact with TRIM27.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000133246 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032739 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (Jun 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J Biol Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
  6. Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMC 533979. PMID 15572693.
  7. "Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1".
  8. Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10): 1319–29. doi:10.1242/jcs.111.10.1319. PMID 9570750.

Further reading
  • Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia". Oncogene. 13 (5): 971–82. PMID 8806687.
  • Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD (1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10): 1319–29. doi:10.1242/jcs.111.10.1319. PMID 9570750.
  • Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell. 7 (6): 1233–43. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826.
  • Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR". Methods Mol. Med. 125: 115–26. doi:10.1385/1-59745-017-0:115. ISBN 1-59745-017-0. PMID 16502581.
  • Mokany E, Todd AV, Fuery CJ, Applegate TL (2006). "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR". Methods Mol. Med. 125: 127–47. doi:10.1385/1-59745-017-0:127. ISBN 1-59745-017-0. PMID 16502582.
  • Heuer K, Sylvester M, Kliche S, Pusch R, Thiemke K, Schraven B, Freund C (2006). "Lipid-binding hSH3 domains in immune cell adapter proteins". J. Mol. Biol. 361 (1): 94–104. doi:10.1016/j.jmb.2006.06.004. PMID 16831444.


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