POLR2I

POLR2I
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IYD, 5IY8, 5IY6, 5IYA, 5IYC, 5IY7, 5IY9, 5IYB
Identifiers
Aliases	POLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I
External IDs	OMIM: 180662 MGI: 1917170 HomoloGene: 4541 GeneCards: POLR2I
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	36,115,213 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	29,932,815 bp[2]
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; amygdala; ; putamen; ; gastrocnemius muscle; ; caudate nucleus; ; prefrontal cortex; ; Brodmann area 9; ; right uterine tube; ; hypothalamus; ; cingulate gyrus;
	Top expressed in
	internal carotid artery; ; medial ganglionic eminence; ; external carotid artery; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; fossa; ; condyle; ; neural tube; ; maxillary prominence; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; nucleic acid binding; DNA-directed 5'-3' RNA polymerase activity;
Cellular component	nucleolus; RNA polymerase II, core complex; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; mRNA cleavage; RNA metabolic process; regulation of gene silencing by miRNA; maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5438
	69920
	ENSG00000105258
	ENSMUSG00000019738
	P36954
	P60898
	NM_006233
	NM_027259
	NP_006224
	NP_081535
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.[5]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.[6]

References

GRCh38: Ensembl release 89: ENSG00000105258 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019738 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
"Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa".

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
Acker J, Wintzerith M, Vigneron M, Kedinger C (1994). "Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II". Nucleic Acids Res. 21 (23): 5345–50. doi:10.1093/nar/21.23.5345. PMC 310569. PMID 8265347.
Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi:10.1074/jbc.271.44.27888. PMID 8910388.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105258 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019738 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8034326-5] Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.

[entrez-6] "Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa".

POLR2I

References

Further reading