PLEKHA1

PLEKHA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EAZ
Identifiers
Aliases	PLEKHA1, TAPP1, pleckstrin homology domain containing A1
External IDs	OMIM: 607772 MGI: 2442213 HomoloGene: 11001 GeneCards: PLEKHA1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	122,442,602 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	130,515,042 bp[2]
RNA expression pattern
	Top expressed in
	sperm; ; Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; synovial joint; ; endothelial cell; ; superior frontal gyrus; ; vulva; ; entorhinal cortex; ; human penis;
	Top expressed in
	ciliary body; ; olfactory bulb; ; iris; ; pineal gland; ; sciatic nerve; ; entorhinal cortex; ; superior frontal gyrus; ; islet of Langerhans; ; right lung; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; lipid binding;
Cellular component	cytoplasm; membrane; nucleoplasm; ruffle membrane; extracellular exosome; nucleus; cytosol; plasma membrane;
Biological process	B cell receptor signaling pathway; roof of mouth development; negative regulation of protein kinase B signaling; luteinization; Leydig cell differentiation; estrogen metabolic process; androgen metabolic process; ruffle organization; multicellular organism growth; establishment of protein localization; skeletal system morphogenesis; post-embryonic development; female gonad development; spermatogenesis; phosphatidylinositol 3-kinase signaling; platelet-derived growth factor receptor signaling pathway; face morphogenesis; cellular response to hydrogen peroxide; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	59338
	101476
	ENSG00000107679
	ENSMUSG00000040268
	Q9HB21
	Q8BUL6
	NM_001001974; NM_001195608; NM_021622; NM_001330178
NM_133942; NM_001346515; NM_001357696; NM_001382373; NM_001382374;
	NM_001382375; NM_001382376; NM_001382377; NM_001382378; NM_001382379
NP_001001974; NP_001182537; NP_001317107; NP_067635; NP_001364159;
	NP_001364160; NP_001364161; NP_001364163; NP_001364164; NP_001364166; NP_001364167; NP_001364169; NP_001364170; NP_001364171; NP_001364172; NP_001364173; NP_001364174; NP_001364175; NP_001364176; NP_001364177; NP_001364178; NP_001364179; NP_001364180; NP_001364181; NP_001364182; NP_001364183; NP_001364184; NP_001364185; NP_001364186; NP_001364187
NP_001333444; NP_598703; NP_001344625; NP_001369302; NP_001369303;
	NP_001369304; NP_001369305; NP_001369306; NP_001369307; NP_001369308
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.[5][6][7]

Interactions

PLEKHA1 has been shown to interact with MPDZ.[8]

References

GRCh38: Ensembl release 89: ENSG00000107679 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040268 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, Maekawa K, Gee SH (Dec 2004). "The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization". J Biol Chem. 279 (51): 53717–24. doi:10.1074/jbc.M410654200. PMID 15485858.
"Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1".
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (Feb 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM (2001). "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity". Biochem. J. 358 (Pt 2): 287–94. doi:10.1042/0264-6021:3580287. PMC 1222060. PMID 11513726.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.
Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S (2002). "TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
Kimber WA, Deak M, Prescott AR, Alessi DR (2003). "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1". Biochem. J. 376 (Pt 2): 525–35. doi:10.1042/BJ20031154. PMC 1223793. PMID 14516276.
Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB (2006). "Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26". Am. J. Hum. Genet. 77 (3): 389–407. doi:10.1086/444437. PMC 1226205. PMID 16080115.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107679 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040268 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11001876-5] Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.

[pmid15485858-6] Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, Maekawa K, Gee SH (Dec 2004). "The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization". J Biol Chem. 279 (51): 53717–24. doi:10.1074/jbc.M410654200. PMID 15485858.

[entrez-7] "Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1".

[pmid11802782-8] Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (Feb 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

PLEKHA1

Interactions

References

Further reading