PLCD4

PLCD4
Identifiers
Aliases	PLCD4, phospholipase C delta 4
External IDs	OMIM: 605939 MGI: 107469 HomoloGene: 88782 GeneCards: PLCD4
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	218,637,184 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	74,606,953 bp[2]
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; gastrocnemius muscle; ; skeletal muscle tissue; ; biceps brachii; ; deltoid muscle; ; tibialis anterior muscle; ; gastric mucosa; ; sural nerve; ; pituitary gland; ; anterior pituitary;
	Top expressed in
	triceps brachii muscle; ; knee joint; ; vastus lateralis muscle; ; seminiferous tubule; ; spermatid; ; sternocleidomastoid muscle; ; spermatocyte; ; tibialis anterior muscle; ; skeletal muscle tissue; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; phospholipase C activity; calcium ion binding; hydrolase activity; signal transducer activity; metal ion binding; phosphatidylinositol phospholipase C activity;
Cellular component	plasma membrane; nuclear membrane; intracellular anatomical structure; endoplasmic reticulum; nucleus; membrane; cytoplasm; endoplasmic reticulum membrane; cytosol;
Biological process	lipid catabolic process; acrosome reaction; intracellular signal transduction; phosphatidylinositol metabolic process; signal transduction; lipid metabolism; inositol phosphate metabolic process; inositol trisphosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	84812
	18802
	ENSG00000115556
	ENSMUSG00000026173
	Q9BRC7
	Q8K3R3
	NM_032726
	NM_001081456; NM_148937
	NP_116115
	NP_001074925; NP_683739
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000115556 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026173 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683. S2CID 40877378.
Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
"Entrez Gene: PLCD4 phospholipase C, delta 4".

Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. S2CID 20562627.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. S2CID 25410140.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
Ananthanarayanan B, Das S, Rhee SG, et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lee SB, Várnai P, Balla A, et al. (2004). "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme". J. Biol. Chem. 279 (23): 24362–71. doi:10.1074/jbc.M312772200. PMID 15037625.
Leung DW, Tompkins C, Brewer J, et al. (2004). "Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells". Mol. Cancer. 3: 15. doi:10.1186/1476-4598-3-15. PMC 420486. PMID 15140260.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chae SW, Kim JM, Yun YP, et al. (2007). "Identification and analysis of the promoter region of the human PLC-delta4 gene". Mol. Biol. Rep. 34 (2): 69–77. doi:10.1007/s11033-006-9014-x. PMID 17394098. S2CID 24577383.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115556 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026173 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10702683-5] Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683. S2CID 40877378.

[pmid9056492-6] Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.

[entrez-7] "Entrez Gene: PLCD4 phospholipase C, delta 4".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PLCD4

References

Further reading