Oxytocin receptor agonist

An oxytocin receptor agonist is a compound that acts as an agonist of the oxytocin receptor.[1][2] Examples include peptide oxytocin receptor agonists like oxytocin (Pitocin, Syntocinon), carbetocin (Duratocin, Pabal), and demoxytocin (Sandopart) and small-molecule oxytocin receptor agonists like TC OT 39, WAY-267464, and LIT-001.[1][2] Oxytocin receptor agonists are used medically to induce labor, promote lactation, and for other uses.[3] In addition, oxytocin receptor agonists are of theoretical interest for the potential treatment of social disorders, such as autism and social anxiety.[1][2] Small-molecule oxytocin receptor agonists are considered to be more promising for such uses due to better pharmacokinetic profiles, such as blood–brain barrier permeability, elimination half-lives, and potential for oral bioavailability.[1][2]

Oxytocin, an example of an oxytocin receptor agonist.

References
  1. Nashar PE, Whitfield AA, Mikusek J, Reekie TA (2022). "The Current Status of Drug Discovery for the Oxytocin Receptor". Oxytocin. Methods Mol Biol. Vol. 2384. pp. 153–174. doi:10.1007/978-1-0716-1759-5_10. ISBN 978-1-0716-1758-8. PMID 34550574. S2CID 239090096.
  2. Gulliver D, Werry E, Reekie TA, Katte TA, Jorgensen W, Kassiou M (January 2019). "Targeting the Oxytocin System: New Pharmacotherapeutic Approaches". Trends Pharmacol Sci. 40 (1): 22–37. doi:10.1016/j.tips.2018.11.001. PMID 30509888. S2CID 54559394.
  3. Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G (October 2010). "REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy". CNS Neurosci Ther. 16 (5): e138–56. doi:10.1111/j.1755-5949.2010.00185.x. PMC 2972642. PMID 20626426.



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