Otu deubiquitinase 5

OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. [3]

OTUD5
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesOTUD5, DUBA, OTU deubiquitinase 5, MCAND
External IDsOMIM: 300713 HomoloGene: 136483 GeneCards: OTUD5
Orthologs
SpeciesHumanMouse
Entrez

55593

n/a

Ensembl

ENSG00000068308

n/a

UniProt

Q96G74

n/a

RefSeq (mRNA)

NM_001136157
NM_001136158
NM_001136159
NM_017602

n/a

RefSeq (protein)

NP_001129629
NP_001129630
NP_001129631
NP_060072

n/a

Location (UCSC)Chr X: 48.92 – 48.96 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

References
  1. GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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