N-acetylneuraminate 4-O-acetyltransferase
In enzymology, a N-acetylneuraminate 4-O-acetyltransferase (EC 2.3.1.44) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + N-acetylneuraminate CoA + N-acetyl-4-O-acetylneuraminate
| N-acetylneuraminate 4-O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.44 | ||||||||
| CAS no. | 51004-25-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its two products are CoA and N-acetyl-4-O-acetylneuraminate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase. This enzyme is also called sialate O-acetyltransferase.
References
- Schauer R (May 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 351 (5): 595–602. PMID 5446640.
- Schauer R (June 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 351 (6): 749–58. doi:10.1515/bchm2.1970.351.1.749. PMID 5425947.
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