Mr. Novak

• Vince Howard as Mr. Peter Butler
• Marian Collier as Marilyn Scott
• Jeanne Bal as Jean Pagano
• Andre Philippe as Mr. Everett Johns
• Kathleen Ellis as Ann Floyd
• Larry Thor as Jim Hendricks
• Phyllis Avery as Ruth Wilkinson
• Stephen Roberts as Mr. Stan Peeples
• Steve Franken as Jerry Allen
• Charles Briles as Ken
• Bill Zuckert as Mr. Arthur Bradwell
• Marion Ross as Miss Bromfield
• Ann Loos as Mrs. Danfield
• David Saber as Toby

• Claude Akins, as Lou Myerson in "One Monday Afternoon" (1964)
• Eddie Albert, as Charlie O'Rourke in "Visions of Sugar Plums" (1964)
• Frank Albertson, as Jim O'Neal in "The Death of a Teacher" (1964)
• Edward Andrews, in "The Song of Songs" (1964)
• Tige Andrews, as Lt. Charles Green in "A Single Isolated Incident" (1963)
• Ed Asner, twice as Harmon Stern and Paul Berg
• Frankie Avalon, as David Muller in "A Thousand Voices" (1963)
• Phyllis Avery, three episodes as Mrs. Ruth Wilkinson
• Diane Baker, as Mrs. Chase in "A Feeling for Friday" (1963)
• Jeanne Bal, two episodes as assistant vice-principal Jean Pagano
• Don "Red" Barry, as Anthony Gallo in "First Year, First Day" (series premiere, 1963)
• Toni Basil as Randy in "One Way to Say Goodbye" (1964)
• Herschel Bernardi, as Mr. Otis in "I Don't Even Live Here" (1963)
• Tony Bill, as Chris Herrod in "An Elephant Is Like a Tree" (1965)
• Whit Bissell, as Karl Bellini in "May Day, May Day" (1965)
• Shirley Bonne, as Susan Hotchkiss in "Sparrow on the Wire" (1964)
• Peter Breck, as Dr. Ted Dietrich in "A Feeling for Friday" (1963)
• Beau Bridges, three episodes, 1963-1965
• Geraldine Brooks, as Claire Andreas in "Love Among the Grown-Ups" (1964)
• Brooke Bundy, three episodes in different roles, including as Patrice Morgan in "X Is the Unknown Factor" (1963)
• Macdonald Carey, as Mr. Edwards in "Pay the Two Dollars" (1963)
• Virginia Christine, as Mrs. Payne in "The Exile" (1964)
• Jeanne Cooper, as Louise Sargent in "The Boy Without a Country" (1963)
• Noreen Corcoran, as Cathy Williams in "Fair The Well" (1964)
• Johnny Crawford, two episodes, as JoJo Rizzo in "Let's Dig a Little Grammar" (1964) and as a delegate from the Soviet Union in "The Tender Twigs" (1965)
• Robert L. Crawford Jr., brother of Johnny Crawford, as a Cuban delegate in "The Tender Twigs" (1965)
• Pat Crowley, as Ariel Wilder in "Love in the Wrong Decision" (1963)
• Robert Culp, as Frank Menlo in "The Tender Twigs" (1965)
• Royal Dano, as Mr. Metcalfe in "To Break a Camel's Back" (1963)
• Kim Darby, two episodes, one as Judy Wheeler (1965)
• Bobby Diamond, as Gus in "Visions of Sugar Plums" (1964)
• Micky Dolenz, as Ed in "Born of Kings and Angels" (1964)
• Tony Dow was cast five times from 1963 to 1965, three as George.
• Howard Duff, as Joe Stillman in "Mountains to Climb" (1965)
• Leo Durocher, as himself in "Boy Under Glass" (1964)
• Ross Elliott, two episodes (1963-1964)
• Richard Eyer, as Jeff in "Day in the Year" (1964)
• Shelly Fabares, two episodes as Dani Cooper (1964-1965)
• Norman Fell, as Barney Sanders in "And Then I Wrote ..." (1965)
• Frank Ferguson, as Stanley Novak in "Moonlighting" (1964)
• James Flavin, as Fire Chief Hawkins in "Beyond a Reasonable Doubt" (1964)
• Steven Franken, twice as Jerry Allen (1963)
• Bonnie Franklin, as Sally in "How Does Your Garden Grow?" and in "The People Doll: You Wind It Up, and It Makes Mistakes" (both 1964)
• Arthur Franz, two episodes as Det. Sgt. Sol Moss (1964)
• Teri Garr, as Lisa in "How Does Your Garden Grow?" (1964)
• Kathy Garver, in "Sparrow on the Wire" (1964)
• Lillian Gish, as Maude Phipps in "Hello, Miss Phipps" (1963)
• Don Grady, as Joey Carter (1964) and as Hank Nelby in "Once a Clown" (1965 series finale)
• Pat Harrington Jr., as Thomas Kelly in "There's a Penguin in My Garden" (1965)
• Joey Heatherton, as Holly Metcalfe in "To Break a Camel's Back" (1963)
• Peter Helm appeared three times, including the lead guest-star role in "The Private Life of Douglas Morgan Jr." (1964)
• Cheryl Holdridge, as Betty in "The Private Life of Douglas Morgan Jr." (1964)
• Celeste Holm, as Rose Herrod in "An Elephant Is Like a Tree" (1965)
• Sherry Jackson, as Cathy Ferguson in "The Risk" (1963)
• Arch Johnson, two episodes, once as Coach Brewer (1964)
• Zalman King in "An Elephant Is Like a Tree (1965) as Troubled Youth
• Tommy Kirk, as Tod Seaton in "Love in the Wrong Season" (1963)
• Walter Koenig Appeared in Three Episodes
• Diane Ladd, as Mrs. Otis in "I Don't Really Live Here" (1963)
• Martin Landau, two episodes as Victor Rand (1963) and as Robert Coolidge in "Enter a Strange Animal" (1965)
• Cloris Leachman, as Dorothy Hummer in the two-part episode "Faculty Follies" (1965)
• Harvey Lembeck, as Vic Rizzo in "Let's Dig a Little Grammar" (1964)
• Peggy Lipton, as Selma in "And Then I Wrote ..." (1965)
• June Lockhart, as Mrs. Nelby, mother of the Don Grady character, in "Once a Clown" (1965)
• Robert Logan, as Jerry Hendricks in "Johnny Ride the Pony: One, Two, Three" (1964)
• Claudine Longet, as Sharhri Javid in "The Silent Dissauders" (1965)
• Frank Maxwell, two episodes (1964-1965)
• Kevin McCarthy, as Mr. Williams in "Fair the Well" (1964)
• Tim McIntire, two episodes (1963-1964)
• Vera Miles, as Sister Gervaise in "There's a Penguin in My Garden" (1965)
• Patricia Morrow, four episodes as different characters
• Edward Mulhare, as Rand Hardy in "He Who Can Does" (1963)
• Lois Nettleton, as Jean Corcoran in "Where Is There to Go, Billie, But Up?" (1965)
• Simon Oakland, as Carl Green in "With a Hammer in His Hand, Lord, Lord!" (1964)
• Nehemiah Persoff, as Henry Selkirk in "Enter a Strange Animal" (1965)
• Michael J. Pollard, as Go-Go Reader in "Honor--and All That" (1965)
• Denver Pyle, as Brill in "Johnny Ride the Pony: One, Two, Three" (1964)
• Robert Random, three episodes (1964-1965)
• Tommy Rettig, as Frank in "The Firebrand" (1965)
• Katharine Ross, as Mrs. Bellway in "Faculty Follies, Part II" (1965)
• Marion Ross, as Nurse Bromfield in "Fair the Well" (1964)
• Tommy Sands, two episodes (1964-1965)
• Brenda Scott, as Sue Johnson in "Fear Is a Handful of Dust"(1964)
• Alexander Scourby, two episodes (1963-1964)
• Frank Silvera, as Andy Towner in "Boy Under Glass" (1964)
• Mark Slade, three episodes (1964-1965)
• Julie Sommars, as Ellen Cable in "The Firebrand" (1965)
• Tisha Sterling, as Myra in "The Firebrand" (1965)
• Harold J. Stone as Joe Garvin in "Beat the Plowshares, Edge the Sword" (1965)
• Maxine Stuart, as Angie (1963) and Miss Gardner (1964)
• Karl Swenson, as Mr. Haskell in "Love Among the Grown-Ups" (1964)
• George Takei, as Walter in "A Feeling for Friday" (1963)
• Buck Taylor, three episodes (1964-1965)
• Malachi Throne, four episodes (1964-1965)
• Joan Tompkins, as Mrs. Douglas Morgan Sr., in "The Private Life of Douglas Morgan Jr." (1964)
• Harry Townes, two episodes, including the role of Frank Dever in "The Death of a Teacher" (1964)
• Lurene Tuttle, as Mrs. Grange in "The Risk" (1963)
• Susan Tyrrell, in her first acting role as Phyllis Freuchen in "Beyond a Reasonable Doubt" (1964)
• Joyce Van Patten, as Avis Brown in "From the Brow of Zeus" (1965)
• June Vincent, as Mrs. Wilder in "Love in the Wrong Season" (1963)
• Beverly Washburn, two episodes (1964-1965)
• Michael Winkelman, three episodes (1963)

The school seen in Mr. Novak duplicated Los Angeles' John Marshall High School "complete to walks, shrubs, and parking."[4] After using the school itself for the pilot, the duplicate was built at the Metro-Goldwyn-Mayer studios, the "largest permanent set to be constructed [there] in a number of years."[4] The complete set filled an acre at the studio. Other construction on the MGM sound stages included duplicates of corridors and classrooms.[4] Exteriors for the fictional Jefferson High School were filmed at both John Marshall High School and Hamilton High School near Culver City.[3]