Monolysocardiolipin

Monolysocardiolipin (MLCL) is a phospholipid with three fatty acid chains located in the inner membrane of mitochondria.

Chemical structure of MLCL backbone

MLCL is normally present as part of the metabolic cycle of mitochondrial lipids, such as cardiolipin.[1] It is remodeled by the enzymes monolysocardiolipin acyltransferase, lysocardiolipin acyltransferase, and tafazzin, which transfer a fourth fatty acid chain onto the phospholipid.[2]

References
  1. Ma BJ, Taylor WA, Dolinsky VW, Hatch GM (1999). "Acylation of monolysocardiolipin in rat heart". J Lipid Res. 40 (10): 1837–45. doi:10.1016/S0022-2275(20)34900-2. PMID 10508203.
  2. Taylor, W. A.; Hatch, G. M. (2009). "Identification of the Human Mitochondrial Linoleoyl-coenzyme A Monolysocardiolipin Acyltransferase (MLCL AT-1)". Journal of Biological Chemistry. 284 (44): 30360–30371. doi:10.1074/jbc.M109.048322. ISSN 0021-9258. PMC 2781591. PMID 19737925.


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