Methylamine-corrinoid protein Co-methyltransferase
Methylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.248, mtmB (gene), monomethylamine methyltransferase) is an enzyme with systematic name monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- methylamine + [Co(I) methylamine-specific corrinoid protein] [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
| Methylamine-corrinoid protein Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.248 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in methanogenesis from methylamine.
References
- Burke SA, Krzycki JA (June 1997). "Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". The Journal of Biological Chemistry. 272 (26): 16570–7. doi:10.1074/jbc.272.26.16570. PMID 9195968.
- Burke SA, Lo SL, Krzycki JA (July 1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". Journal of Bacteriology. 180 (13): 3432–40. PMC 107300. PMID 9642198.
- Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Current Opinion in Chemical Biology. 8 (5): 484–91. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
External links
- Methylamine---corrinoid+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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