Merafloxacin

Merafloxacin
Identifiers
	IUPAC name 1-Ethyl-7-[3-(ethylaminomethyl)pyrrolidin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid;
CAS Number	91188-00-0 ;
PubChem CID	121833;
ChemSpider	108697;
UNII	G6U51T1K77;
ChEMBL	ChEMBL6209;
CompTox Dashboard (EPA)	DTXSID40869517 ;
Chemical and physical data
Formula	C19H23F2N3O3
Molar mass	379.408 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F;
	InChI InChI=1S/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27); Key:BAYYCLWCHFVRLV-UHFFFAOYSA-N;

Merafloxacin is a fluoroquinolone antibacterial that inhibits the pseudoknot formation which is necessary for the frameshift in the SARS-CoV-2 genome.[1] It is a promising drug candidate for SARS-CoV-2.[2]

References

Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, et al. (June 2021). "Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome". Science. 372 (6548): 1306–1313. Bibcode:2021Sci...372.1306B. doi:10.1126/science.abf3546. PMC 8168617. PMID 34029205.
Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU (October 2020). "Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro". bioRxiv. doi:10.1101/2020.10.21.349225. PMC 7587830. PMID 33106809.

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[1] Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, et al. (June 2021). "Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome". Science. 372 (6548): 1306–1313. Bibcode:2021Sci...372.1306B. doi:10.1126/science.abf3546. PMC 8168617. PMID 34029205.

[Sun-2] Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU (October 2020). "Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro". bioRxiv. doi:10.1101/2020.10.21.349225. PMC 7587830. PMID 33106809.