Medronic acid

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, 99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

Not to be confused with mildronate or minodronate.
Medronic acid
Names
Preferred IUPAC name
Methylenebis(phosphonic acid)
Other names
methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.016.229
KEGG
UNII
  • InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) checkY
    Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N checkY
  • O=P(O)(O)CP(=O)(O)O
Properties
CH6O6P2
Molar mass 176.001 g·mol−1
Melting point 199 to 200 °C (390 to 392 °F; 472 to 473 K)[1]
Hazards
Lethal dose or concentration (LD, LC):
45-50 mg/kg (i.v., mice, rabbits)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References
  1. Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123
  • "Medronic acid". Drug Information Portal. U.S. National Library of Medicine.
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