MPP2

MPP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E7K
Identifiers
Aliases	MPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDs	OMIM: 600723 MGI: 1858257 HomoloGene: 3920 GeneCards: MPP2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	43,909,711 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	101,979,341 bp[2]
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; hypothalamus; ; Brodmann area 9; ; cingulate gyrus; ; amygdala; ; substantia nigra; ; Brodmann area 10; ; inferior olivary nucleus; ; hippocampus proper; ; secondary oocyte;
	Top expressed in
	subiculum; ; superior frontal gyrus; ; piriform cortex; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; primary motor cortex; ; habenula; ; dorsal tegmental nucleus; ; olfactory tubercle; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanylate kinase activity; protein binding;
Cellular component	integral component of plasma membrane; postsynaptic density; dendrite membrane; dendritic spine; dendritic shaft; cytoplasm; cytoskeleton; plasma membrane; membrane; dendrite; dendritic spine membrane; cell projection;
Biological process	signal transduction; GMP metabolic process; GDP metabolic process; protein homooligomerization; excitatory postsynaptic potential; long-term potentiation;
	Sources:Amigo / QuickGO
Orthologs
	4355
	50997
	ENSG00000108852
	ENSMUSG00000017314
	Q14168
	Q9WV34
NM_001278370; NM_001278371; NM_001278372; NM_001278373; NM_001278374;
	NM_001278375; NM_001278376; NM_001278381; NM_005374
	NM_016695; NM_001356324
NP_001265299; NP_001265300; NP_001265301; NP_001265302; NP_001265303;
	NP_001265304; NP_001265305; NP_001265310; NP_005365
	NP_057904; NP_001343253
	Wikidata
View/Edit Human	View/Edit Mouse

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.[5][6]

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

References

GRCh38: Ensembl release 89: ENSG00000108852 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000017314 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
"Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Smith SA, Holik P, Stevens J, et al. (1997). "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21". Genomics. 31 (2): 145–50. doi:10.1006/geno.1996.0025. PMID 8824795.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wierstra I, Alves J (2006). "Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains". Biol. Chem. 387 (7): 963–76. doi:10.1515/BC.2006.120. PMID 16913846. S2CID 25571232.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108852 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017314 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7590743-5] Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.

[entrez-6] "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

MPP2

References

Further reading