MIRLET7F2
MicroRNA let-7f-2 is a protein that in humans is encoded by the MIRLET7F2 gene. [3]
| MIRLET7F2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MIRLET7F2, LET7F2, MIRNLET7F2, let-7f-2, microRNA let-7f-2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300721 GeneCards: MIRLET7F2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- GRCh38: Ensembl release 89: ENSG00000208012 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA let-7f-2". Retrieved 2017-11-07.
Further reading
- Li Z, Wu F, Brant SR, Kwon JH (2011). "IL-23 receptor regulation by Let-7f in human CD4+ memory T cells". J. Immunol. 186 (11): 6182–90. doi:10.4049/jimmunol.1000917. PMC 3133967. PMID 21508257.
- Zheng H, Zhang L, Zhao Y, Yang D, Song F, Wen Y, Hao Q, Hu Z, Zhang W, Chen K (2013). "Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer". PLOS ONE. 8 (11): e77853. Bibcode:2013PLoSO...877853Z. doi:10.1371/journal.pone.0077853. PMC 3815222. PMID 24223734.
- Yan S, Han X, Xue H, Zhang P, Guo X, Li T, Guo X, Yuan G, Deng L, Li G (2015). "Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin". J. Cell. Biochem. 116 (8): 1680–92. doi:10.1002/jcb.25128. PMID 25735962. S2CID 1484204.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.