MFSD1

MFSD1
Identifiers
Aliases	MFSD1, SMAP4, major facilitator superfamily domain containing 1, Minerva
External IDs	MGI: 1914118 HomoloGene: 11228 GeneCards: MFSD1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	158,829,719 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	67,511,570 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; cancellous bone; ; palpebral conjunctiva; ; visceral pleura; ; parietal pleura; ; gums; ; parotid gland; ; cavity of mouth; ; tibia; ; vulva;
	Top expressed in
	yolk sac; ; kidney; ; proximal tubule; ; olfactory epithelium; ; primitive streak; ; submandibular gland; ; calvaria; ; renal corpuscle; ; left lobe of liver; ; trigeminal ganglion;
	More reference expression data
	n/a
Orthologs
	64747
	66868
	ENSG00000118855
	ENSMUSG00000027775
	Q9H3U5
	Q9DC37
	NM_001167903; NM_001289406; NM_001289407; NM_022736
	NM_025813
	NP_001161375; NP_001276335; NP_001276336; NP_073573
	NP_080089
	Wikidata
View/Edit Human	View/Edit Mouse

Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan.[5] It is an Atypical solute carrier.[6]

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes [6] and lysosomes.[7][8]

HGNC:25874

MFSD1 belongs to AMTF6.[9]

References

GRCh38: Ensembl release 89: ENSG00000118855 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027775 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.
Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.
Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118855 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027775 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[:0-6] Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.

[7] Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.

[8] Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.

[9] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.