Liranaftate

Liranaftate
Clinical data
Trade names	Zefnart
Other names	M-732; piritetrate
Routes of; administration	Topical
ATC code	D01AE25 (WHO) ;
Legal status
Legal status	JP: Rx-only;
Identifiers
	IUPAC name O-(5,6,7,8-Tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate;
CAS Number	88678-31-3;
PubChem CID	3936;
ChemSpider	3799;
UNII	5253IGO5X3;
KEGG	D01550;
CompTox Dashboard (EPA)	DTXSID6046470 ;
Chemical and physical data
Formula	C18H20N2O2S
Molar mass	328.43 g·mol−1

Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3][4]

Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.[5]

References

Koga H, Nanjoh Y, Makimura K, Tsuboi R (2009). "In vitro antifungal activities of luliconazole, a new topical imidazole". Medical Mycology. 47 (6): 640–7. doi:10.1080/13693780802541518. PMID 19115136.
"Torii Pharmaceutical to Launch Antifungal Agent for External Use, "ZEFNART SOLUTION 2%", in Japan" (Press release). Torii Pharmaceutical Co. Retrieved June 27, 2021.
"Liranaftate". ncats.io. Retrieved June 27, 2021.
"Liranaftate". Adis Insight. Retrieved June 27, 2021.
"Liranaftate". targetmol.com. Retrieved June 27, 2021.

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