Lessons in Chemistry (novel)

Lessons in Chemistry comes after nearly 100 rejections of prior works by Garmus. The publishing rights to the book were auctioned. The book was originally called "Introduction to Chemistry", but was later renamed by the author's agent, Felicity Blunt.[5]

The book was inspired by Garmus's own experience of her work as a creative director in an advertising agency, in particular after a frustrating meeting in which a male co-worker took credit for one of her ideas. During the writing, Garmus was a full time copywriter and self-studied chemist, attempting experiments from the The Golden Book of Chemistry Experiments. Garmus said in an interview with the Los Angeles Times that "the fire department had to come twice for the amount of flames in my flat".[6] The author also adapted her own interest in rowing as a hobby of the protagonist, Zott.[4] Aside from rowing, Garmus said that she doesn't share other commonalities with the Zott, instead claiming to have written her "role model".[7]

The rights for a film adaptation were sold by auction. Prior to the auction, the eventual winner, Brie Larson, video called the author asking for her permission. Garmus claimed in an interview to have given minimal input to the script writing and production of the TV adaption.[8]

After her application as a doctoral student was rejected, Elizabeth Zott works at Hastings Research Institute as a chemist. She meets fellow Hastings researcher Calvin Evans while taking surplus beakers from his lab. Evans assumes that she is a secretary and ignores her. They later encounter each other at a theater, Calvin, experiencing food poisoning, vomits on Zott. They start dating and living together shortly after.

Evans proposes in the staff dining room, but Zott rejects him, citing concerns over her research being credited to his name. A month later, Zott adopts an abandoned explosive detection dog and names him Six-Thirty. Evans convinces Zott to begin to row, and Zott starts teaching her dog English.

Due to a local law, Zott buys a leash for Six-Thirty. The leash indirectly causes Evans' skull to be fractured in a fatal accident. She later finds herself pregnant with his child, which leads to her being fired from Hastings. She decides to continue her research by converting her kitchen into a lab, obtaining income by offering research advice to former colleagues. During this, Six-Thirty starts communicating and teaching her unborn child words. Zott seeks support for her pregnancy with Dr. Mason, who used to row with her. Months later, she gives birth to Madeline. Afterwards, Harriet Sloane, her neighbor, comes to offer support.

Three years later, Zott decides to enroll Madeline in kindergarten early, modifying her birth certificate to do so. Because of financial difficulties, Zott attempts to return to Hastings. The head of the chemistry department, Dr. Donatti, allows her to be hired, but demotes her to a laboratory technician. During an argument with her coworker, Miss Frask, Zott discovers that Frask had been sexually assaulted by a thesis advisor, an experience they share which stopped them both from obtaining their PhDs. Frask is later fired for gaining weight. Before leaving, Frask gives Zott Evans' files that were left in Hastings.

Two months after returning to Hastings, Donatti plagiarizes Zott's work. She confronts him and resigns. At home, Zott discovers that a classmate is eating Madeline’s lunch. She goes to talk to the girl's father, Walter Pine. Pine, a local television producer, offers her a job as a cooking show host due to her unique personality. During the debut, Zott ignores the cue cards that Pine had written for her, which is met with disapproval.

Having been assigned a school project to make a family tree, Madeline searches for Evans' orphanage. She meets Reverend Wakely during the project who recalls that he was pen pals with Evans during college and promises to call the orphanage for her and to look for its mysterious donor. At work, Zott is called in to the executive producer, Phil Lebensmal's office. Lebensmal fires her citing her rebellious attitude, then attempts to sexually assault her. She draws a kitchen knife and Lebensmal proceeds to have a heart attack. Zott calls an ambulance and, while waiting, discovers syndication and sponsorship offers not revealed to Pine. Lebensmal does not return to work, making Pine the executive producer.

After turning down multiple magazine interview offers, she accepts Franklin Roth’s interview for Life. Roth writes a positive article, which is rejected multiple times. His editor publishes a modified one with a negative tone and excessive personal details. Prior to publication, Roth leaves an envelope with the unpublished original at Zott's doorstep. Madeline takes it and gives it to Frask, who is working as Wakely’s secretary and she proceeds to read it. Wakely comes to Zott’s residence to speak to Madeline after the article's publication and gives Zott Roth’s original article. Frask and others write to the editors of the magazine in protest and Frask submits the original article to several other magazines, leading to its publication weeks later in Vogue.

Zott, saddened by the article, resigns as the host of the show, stating that she will be pursuing a career in research. Frask’s letter to Life is noticed by an early investor in Zott’s research, who decides to acquire Hastings and replace Donatti with Zott. The investor reveals that she is Evans' mother and found them due to Madeline's having sent a letter to her foundation thanking her for funding the orphanage. They reminisce about the past and her investment allows Zott to continue her abiogenesis research.

Lessons in Chemistry was named the Barnes & Noble’s book of the year in 2022.[5]

Stephanie Merritt of The Guardian praised the author's ability in creating a "richly comic novel around a character who is entirely deadpan" and called the book "a polished, funny, thought-provoking story" but holding a few flaws common in debut novels, including an unfocused narrative perspective.[3] Karen Heller writing for the The Washington Post called the book an "indelible assemblage of stubborn, idiosyncratic characters" and that there was an "infectious absurdity" to the book and its protagonist.[9] In an article for The New York Times, Elisabeth Egan called the book "irresistible, satisfying and full of fuel" and claimed that "feminism is the catalyst" of the book.[10] Michael Byers from Cascadia Daily News wrote that the "heroine is brave, original and completely unafraid" and claimed that the reasons for its success is clear.[11]

Pippa Bailey writing for the New Statesman criticizes the book, writing that the book was written "craftlessly" with the plot being "predictable". Bailey claimed that the final plot twist was rushed and the character writing seemed monotone, concluding with "Lessons in Chemistry is ultimately a work of fantasy. Elizabeth Zott, our great realist, would hate it."[12]