LY6E

LY6E
Identifiers
Aliases	LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDs	OMIM: 601384 MGI: 106651 HomoloGene: 56411 GeneCards: LY6E
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	143,023,832 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	74,831,754 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; stromal cell of endometrium; ; placenta; ; right lung; ; upper lobe of left lung; ; hippocampus proper; ; left adrenal gland; ; canal of the cervix; ; nucleus accumbens; ; putamen;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; corneal stroma; ; cardiac muscles; ; esophagus; ; entorhinal cortex; ; lip; ; trachea; ; superior frontal gyrus; ; masseter muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor inhibitor activity;
Cellular component	integral component of plasma membrane; membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	cell surface receptor signaling pathway; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4061
	17069
	ENSG00000278032; ENSG00000160932
	ENSMUSG00000022587
	Q16553
	Q64253
	NM_002346; NM_001127213
NM_001164036; NM_001164037; NM_001164038; NM_001164039; NM_001164040;
	NM_008529; NM_001374138
	NP_001120685; NP_002337
NP_001157508; NP_001157509; NP_001157510; NP_001157511; NP_001157512;
	NP_032555; NP_001361067
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[9] Further research is required to validate Ly6E for translation research.

References

ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022587 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. PMID 8757598.
Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
"Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB (1997). "A gain of novel tissue specificity in the human Ly-6 gene E48". J. Immunol. 159 (10): 4879–86. PMID 9366413.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG (1998). "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1". J. Immunol. 160 (1): 197–208. PMID 9551972.
Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T (1998). "Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex". J. Biol. Chem. 273 (20): 12301–6. doi:10.1074/jbc.273.20.12301. PMID 9575182.
Ding L, Shevach EM (2001). "Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen". Immunology. 104 (1): 28–36. doi:10.1046/j.1365-2567.2001.01275.x. PMC 1783287. PMID 11576217.
Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ (2002). "Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland". Mol. Cell. Biol. 22 (3): 946–52. doi:10.1128/MCB.22.3.946-952.2002. PMC 133557. PMID 11784869.
de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH (2003). "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma". Int. J. Cancer. 103 (6): 768–74. doi:10.1002/ijc.10903. PMID 12516096. S2CID 42182637.

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[refGRCh38Ensembl-1] ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022587 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8757598-5] Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. PMID 8757598.

[pmid8650192-6] Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.

[entrez-7] "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".

[8] Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.

[9] Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

LY6E

References

Further reading