LSM2

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.[5][6][7]

LSM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM2, C6orf28, G7B, YBL026W, snRNP, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607282 MGI: 90676 HomoloGene: 48535 GeneCards: LSM2
Orthologs
SpeciesHumanMouse
Entrez

57819

27756

Ensembl

ENSG00000204392

ENSMUSG00000007050

UniProt

Q9Y333

O35900

RefSeq (mRNA)

NM_021177

NM_001110101
NM_001204273
NM_001204274
NM_030597

RefSeq (protein)

NP_067000

NP_001103571
NP_001191202
NP_001191203
NP_085100

Location (UCSC)Chr 6: 31.8 – 31.81 MbChr 17: 35.2 – 35.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

Interactions

LSM2 has been shown to interact with DDX20,[8] LSM3,[9][10][11][12] LSM8[9][10] and LSM7.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000204392 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000007050 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  6. Olavesen MG, Snoek M, Campbell RD (Mar 1993). "Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs". Immunogenetics. 37 (5): 394–6. doi:10.1007/BF00216806. PMID 8428774. S2CID 1809207.
  7. "Entrez Gene: LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  8. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  9. Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  10. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  11. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  12. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9Y333 (U6 snRNA-associated Sm-like protein LSm2) at the PDBe-KB.
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